{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:25:17Z","timestamp":1774743917014,"version":"3.50.1"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>As a key immune cytokine, C\u2010X\u2010C motif chemokine ligand 13 (CXCL13) has been reported to play critical roles in immune control of hepatitis B virus (HBV) infection. We aimed to screen single\u2010nucleotide polymorphisms (SNPs) of <jats:italic>CXCL13<\/jats:italic> for predicting response to pegylated interferon\u2010alpha (PegIFN\u03b1) therapy of chronic hepatitis B (CHB) patients. Two independent cohorts with a total of 945 (Cohort 1, <jats:italic>n<\/jats:italic>\u2009=\u2009238; Cohort 2, <jats:italic>n<\/jats:italic>\u2009=\u2009707) hepatitis B e antigen (HBeAg)\u2010positive CHB patients treated with PegIFN\u03b1 were enrolled in this retrospective cohort study. Eight candidate SNPs were selected through gene\u2010wide SNP mining within or flanking <jats:italic>CXCL13<\/jats:italic>. A polygenic score (PGS) was utilized to assess the cumulative effects of multiple SNPs. The associations of candidate SNPs and PGS with combined response (CR, defined as the combination of HBeAg seroconversion and HBV DNA level &lt;3.3log<jats:sub>10<\/jats:sub> IU\/mL) and hepatitis B surface antigen (HBsAg) level were evaluated. Among the eight candidate SNPs, rs76084459 which is located at upstream of CXC<jats:italic>L13<\/jats:italic> was significantly associated with both CR (<jats:italic>p<\/jats:italic>\u2009=\u20090.002) and HBsAg level (<jats:italic>p<\/jats:italic>\u2009=\u20090.015). A PGS integrating <jats:italic>CXCL13<\/jats:italic>_rs76084459 and five other SNPs, which were previously identified as predictors of PegIFN\u03b1 treatment response, was further strongly correlated with CR (<jats:italic>p<\/jats:italic>\u2009=\u20091.759\u2009\u00d7\u200910<jats:sup>\u221210<\/jats:sup>) and HBsAg level (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). This study demonstrated that <jats:italic>CXCL13<\/jats:italic>_rs76084459 can predict response to PegIFN\u03b1 treatment of HBeAg\u2010positive CHB patients. A PGS composed of six SNPs including <jats:italic>CXCL13<\/jats:italic>_rs76084459 predicts PegIFN\u03b1 treatment response better.<\/jats:p>","DOI":"10.1002\/jmv.28963","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T09:25:24Z","timestamp":1689845124000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["<i>CXCL13<\/i> variant predicts pegylated\u2010interferon \u03b1 treatment response in HBeAg\u2010positive chronic hepatitis B patients"],"prefix":"10.1002","volume":"95","author":[{"given":"Mengqi","family":"Luo","sequence":"first","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institutes of Liver Diseases Research of Guangdong Province, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"},{"name":"The Key Laboratory of Molecular Pathology (Hepatic Diseases) of Guangxi, The Affiliated Hospital of Youjiang Medical University for Nationalities  Baise Guangxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institutes of Liver Diseases Research of Guangdong Province, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chou","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Organ Failure Research, Guangdong Key Laboratory of Viral Hepatitis Research, Institutes of Liver Diseases Research of Guangdong Province, Department of Infectious Diseases and Hepatology Unit, Nanfang Hospital Southern Medical University  Guangzhou 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