{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:20:25Z","timestamp":1780582825506,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) is estimated to affect 0.4%\u20132.5% of the global population. Most cases are unexplained; however, some patients describe an antecedent viral infection or response to antiviral medications. We report here a multicenter study for the presence of viral nucleic acid in blood, feces, and saliva of patients with ME\/CFS using polymerase chain reaction and high\u2010throughput sequencing. We found no consistent group\u2010specific differences other than a lower prevalence of anelloviruses in cases compared to healthy controls. Our findings suggest that future investigations into viral infections in ME\/CFS should focus on adaptive immune responses rather than surveillance for viral gene products.<\/jats:p>","DOI":"10.1002\/jmv.28993","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T12:48:55Z","timestamp":1690894135000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A multicenter virome analysis of blood, feces, and saliva in myalgic encephalomyelitis\/chronic fatigue syndrome"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4819-8963","authenticated-orcid":false,"given":"Thomas","family":"Briese","sequence":"first","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafal","family":"Tokarz","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucinda","family":"Bateman","sequence":"additional","affiliation":[{"name":"Bateman Horne Center Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Che","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Biostatistics, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Guo","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Komal","family":"Jain","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Levine","sequence":"additional","affiliation":[{"name":"Levine Clinic New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mady","family":"Hornig","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Oleynik","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phenix\u2010Lan","family":"Quan","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wai H.","family":"Wong","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent L.","family":"Williams","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Pathology and Cell Biology, College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5241-8914","authenticated-orcid":false,"given":"Suzanne D.","family":"Vernon","sequence":"additional","affiliation":[{"name":"Bateman Horne Center Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy G.","family":"Klimas","sequence":"additional","affiliation":[{"name":"Institute for Neuro\u2010Immune Medicine, College of Osteopathic Medicine Nova Southeastern University Fort Lauderdale Florida USA"},{"name":"Bruce W. Carter Miami Veterans Affairs Medical Center Geriatric Research Education and Research Center Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Peterson","sequence":"additional","affiliation":[{"name":"Sierra Internal Medicine at Incline Village Incline Village USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Montoya","sequence":"additional","affiliation":[{"name":"Jack S. Remington Laboratory for Specialty Diagnostics of Toxoplasmosis Palo Alto Medical Foundation Palo Alto USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Ian Lipkin","sequence":"additional","affiliation":[{"name":"Center for Infection and Immunity, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Epidemiology, Mailman School of Public Health Columbia University New York New York USA"},{"name":"Department of Pathology and Cell Biology, College of Physicians and Surgeons Columbia University New York New York USA"},{"name":"Department of Neurology, College of Physicians and Surgeons Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Beyond Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome: Redefining an Illness","author":"Institute of Medicine","year":"2015"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2021.06.002"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/13550289909045378"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00266-12"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-121-12-199412150-00009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1300\/J092v11n01_02"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23147906"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2023.01.004"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1102.040492"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01703-07"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-0207-4"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01491-15"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.34.7.1666-1671.1996"},{"issue":"2","key":"e_1_2_9_15_1","first-page":"e195","article-title":"Prevalence of human papillomavirus in the saliva of sexually active women with cervical intraepithelial neoplasias","volume":"25","author":"Sanchez\u2010Siles M","year":"2020","journal-title":"Med Oral Patol Oral Cir Bucal"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa190"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-102215-095431"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuaa007"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fviro.2021.782886"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01101-07"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710519114"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.28993","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T02:24:50Z","timestamp":1702434290000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.28993"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":20,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/jmv.28993"],"URL":"https:\/\/doi.org\/10.1002\/jmv.28993","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e28993"}}