{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:57:53Z","timestamp":1790812673507,"version":"4.1.0"},"reference-count":77,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This review examines the recent literature on the management of herpes simplex virus (HSV) infections in neonates. We summarized the three clinical categories of maternal HSV infection during pregnancy (primary first episode, nonprimary first episode, or recurrent episode) and the mechanisms of fetal damage. Considering when the transmission of the infection from the mother to the fetus\/newborn occurs, three types of neonatal infection can be distinguished: intrauterine infection (5% of cases), postnatal infection (10% of cases), and perinatal infections (85% of cases). Neonatal presentation could range from a limited disease with skin, eye, and mouth disease to central nervous system disease or disseminated disease: the treatment with acyclovir should be tailored according to symptoms and signs of infection, and virological tests. These children need a multidisciplinary follow\u2010up, to timely intercept any deviation from normal neurodevelopmental milestones. Prevention strategies remain a challenge, in the absence of an available vaccine against HSV.<\/jats:p>","DOI":"10.1002\/jmv.29024","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:33:18Z","timestamp":1692646398000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Neonatal herpes simplex virus infection: From the maternal infection to the child outcome"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9076-9838","authenticated-orcid":false,"given":"Domenico Umberto","family":"De Rose","sequence":"first","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"},{"name":"Faculty of Medicine and Surgery \u201cTor Vergata\u201d University of Rome Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6622-0485","authenticated-orcid":false,"given":"Sarah","family":"Bompard","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Maddaloni","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iliana","family":"Bersani","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovica","family":"Martini","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Santisi","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Longo","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Paola","family":"Ronchetti","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Dotta","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9820-6557","authenticated-orcid":false,"given":"Cinzia","family":"Auriti","sequence":"additional","affiliation":[{"name":"Neonatal Intensive Care Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS Rome Italy"},{"name":"Saint Camillus International University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnur.2020.05.004"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.19.237149"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2021.1982373"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2020.03.003"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30362-X"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2012-3216"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy318"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199708213370801"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00121-X"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.2.203"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016340601151949"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.07.041"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1185\/030079905X61901"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2021.01.055"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogc.2017.04.016"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2015.05.001"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2009.07402.x"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.10.005"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2014.08.012"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2018.02.004"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12689"},{"key":"e_1_2_17_23_1","first-page":"754","article-title":"Morphological and immunohistochemical features of placental damage in cases of perinatal death: institutional experience with emphasis on viral etiology","volume":"50","author":"Nasyrov RA","year":"2020","journal-title":"Ann Clin Lab Sci"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ruq.0000187025.61943.ff"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-018-4092-1"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.12355"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2007.01.003"},{"key":"e_1_2_17_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piw013"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002846"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0807633"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu381"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piab105"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2008.01.002"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.223"},{"key":"e_1_2_17_35_1","first-page":"223","article-title":"Neonatal herpes simplex virus infection presenting with fever alone","volume":"4","author":"Filippine MM","year":"2001","journal-title":"J Hum Virol"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANC.0000000000000949"},{"key":"e_1_2_17_37_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1385854"},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-241405"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.81.1.F24"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00019-7"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.12.077"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nic.2022.07.017"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/children9081210"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2006.08.003"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2014.07.006"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15314"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-018-2062-9"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.19-2-e89"},{"key":"e_1_2_17_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003840"},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.66.4.495"},{"key":"e_1_2_17_51_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.72.6.778"},{"key":"e_1_2_17_52_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.230"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199102143240703"},{"key":"e_1_2_17_54_1","article-title":"Antiviral agents for treatment of herpes simplex virus infection in neonates","volume":"2009","author":"Jones CA","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_17_55_1","first-page":"680","article-title":"Measuring head circumference: update on infant microcephaly","volume":"61","author":"Harris SR","year":"2015","journal-title":"Can Fam Physician"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003509"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13197"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.3928\/19382359-20170112-01"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90997-X"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piu050"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-6-40"},{"key":"e_1_2_17_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/GCO.0b013e3283294840"},{"key":"e_1_2_17_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104721"},{"key":"e_1_2_17_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2010.02785.x"},{"key":"e_1_2_17_65_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.55"},{"key":"e_1_2_17_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.obstetgynecol.2003.08.015"},{"key":"e_1_2_17_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(71)90580-1"},{"key":"e_1_2_17_68_1","article-title":"Third trimester antiviral prophylaxis for preventing maternal genital herpes simplex virus (HSV) recurrences and neonatal infection","volume":"1","author":"Hollier LM","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_17_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2010.045559"},{"key":"e_1_2_17_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2020.03.004"},{"key":"e_1_2_17_71_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.4.331"},{"key":"e_1_2_17_72_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011915"},{"key":"e_1_2_17_73_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103151"},{"key":"e_1_2_17_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines11020206"},{"key":"e_1_2_17_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2421"},{"key":"e_1_2_17_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073431"},{"key":"e_1_2_17_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301150"},{"key":"e_1_2_17_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541-020-0159-8"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T21:29:29Z","timestamp":1702416569000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":77,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1002\/jmv.29024"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29024","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29024"}}