{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:35Z","timestamp":1753869455036,"version":"3.41.2"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human coronavirus OC43 (HCoV\u2010OC43) often causes common cold and is able to neuroinvasive, but it can also induce lower respiratory tract infections (LRTI) especially in children and the elderly adults with underlying diseases. HCoV\u2010OC43 infections currently have no approved antiviral treatment. Arbidol (ARB) is a broad\u2010spectrum antiviral and is an antiviral medication for the treatment of influenza used in Russia and China. Due to its multiple mechanisms of action, such as inhibition of viral fusion and entry, immunomodulation, and modulation of host cell signaling pathways, ARB has the potential to be an effective treatment option for viral infections. Therefore, the study aims to investigate the activities of ARB against HCoV\u2010OC43 infections. Suckling mice were infected with HCoV\u2010OC43 and treated with ARB (50, 25 and 12.5\u2009mg\/kg\/d) by gavage once daily for 4 days. the survival rates and body weight were recorded, the viral titer was measured by real\u2010time quantitative polymerase chain reaction, cytokine levels were measured by Bio\u2010Plex assays. Histopathological changes of the lungs and brain were analyzed. Our results show ARB increased the survival rate, reduced viral copy numbers in the lung, mitigated pro\u2010inflammatory cytokine production, and improved brain and lung histopathology significantly without any significant toxicity or side effects in vivo. Our results suggest ARB could be a promising approach for the prevention and treatment of HCoV\u2010OC43 while further studies are needed to address these possibilities and the underlying mechanism.<\/jats:p>","DOI":"10.1002\/jmv.29052","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T07:59:30Z","timestamp":1693468770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Arbidol increases the survival rate by mitigating inflammation in suckling mice infected with human coronavirus OC43 virus"],"prefix":"10.1002","volume":"95","author":[{"given":"Hongxia","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Dongguan Institute of Respiratory and Critical Care Medicine, The Tenth Affiliated Hospital of Southern Medical University (Dongguan People's Hospital) Southern Medical University Dongguan 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