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The virus responsible for the disease, the human monkeypox virus (hMPXV), underwent various genetic changes, resulting in the emergence of over a dozen distinct lineages, which could be identified by only a small number of unique mutations. As of January 25, 2023, genomic information of hMPXV generated had reached 4632 accessions in the GISAID database. In this study, we aimed to investigate the epidemiological and phylogenetic characteristics of the B.1.6 sub\u2010lineage of hMPXV in Peru, compared with other circulating sub\u2010lineages during the global outbreak. The B.1.6 sub\u2010lineage, characterized by the 111029G&gt;A mutation, was estimated to have emerged in June 2022 and was found mainly in Peru. Most cases (95.8%) were men with an average age of 33 years, and nearly half of the patients had HIV, of whom only 77.35% received antiretroviral therapy. Our findings revealed that the B.1.6, B.1.4, and B.1.2 sub\u2010lineages were well represented and had a higher number of mutations despite having the lowest media substitution rates per site per year. Moreover, it was estimated that B.1.2 and B.1.4 appeared in February 2022 and were the first two sub\u2010lineages to emerge. A mutation profile was also obtained for each sub\u2010lineage, reflecting that several mutations had a pattern similar to the characteristic mutation. This study provides the first estimation of the substitution rate and ancestry of each monkeypox sub\u2010lineage belonging to the 2022 outbreak. Based on our findings, continued genomic surveillance of monkeypox is necessary to understand better and track the evolution of the virus.<\/jats:p>","DOI":"10.1002\/jmv.29056","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:46:13Z","timestamp":1694004373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sub\u2010lineage B.1.6 of hMPXV in a global context: Phylogeny and epidemiology"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7290-9254","authenticated-orcid":false,"given":"Iris S.","family":"Molina","sequence":"first","affiliation":[{"name":"Area de Innovacion y Desarrollo Tecnol\u00f3gico, Centro Nacional de Salud P\u00fablica Instituto Nacional de Salud Lima 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