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HTLV\u20101 encodes Tax protein that activates transcription from viral long terminal repeats (LTR). Multiple cofactors are involved in the regulation of HTLV\u20101 transcription via association with Tax. Yes\u2010associated protein (YAP), which is the key effector of Hippo pathway, is elevated and activated in ATL cells. In this study, we reported that YAP protein suppressed Tax activation of HTLV\u20101 5\u2032 LTR but not 3\u2032 LTR. The activation of the 5\u2032 LTR by Tax was potentiated when YAP was depleted. Moreover, overexpression of YAP repressed HTLV\u20101 plus\u2010strand viral gene expression and virion production, whereas compromising YAP by RNA inference augmented the expression of HTLV\u20101 protein. As mechanisms of YAP\u2010mediated viral transcription inhibition, we found that YAP interacted with Tax, and prevented the association between Tax and p300. It finally led to the inhibition of recruitment of Tax to the Tax\u2010responsive element in the 5\u2032 LTR of HTLV\u20101. Taken together, our results demonstrate the negative regulatory function of YAP in Tax activation of HTLV\u20101 transcription. It may achieve sufficient transcriptional repression to maintain persistent infection and long\u2010term latency of HTLV\u20101 in the host cells.<\/jats:p>","DOI":"10.1002\/jmv.29065","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T04:53:42Z","timestamp":1693803222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["YAP suppresses human T\u2010cell leukemia virus type 1 transcription"],"prefix":"10.1002","volume":"95","author":[{"given":"Hengbo","family":"Li","sequence":"first","affiliation":[{"name":"School of Medicine Hangzhou City University Hangzhou China"},{"name":"College of Life Sciences Zhejiang Normal University Jinhua China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Zou","sequence":"additional","affiliation":[{"name":"College of Life Sciences Zhejiang Normal University Jinhua 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