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HPV DNA was detected in 82% (<jats:italic>n<\/jats:italic>\u2009=\u2009344) of anal and 11% (<jats:italic>n<\/jats:italic>\u2009=\u200945) of oropharyngeal self\u2010collected samples taken from 421 participants. Multiple HPV types were detected in 70% of anal samples, and single HPV types in 91% of oropharyngeal samples. HPV16 was the most frequent type detected in the anus, followed by HPV6, HPV51, and HPV52. HPV6, HPV16, and HPV11 were the most prevalent types in the oropharynx. HPV targeted by the nonavalent vaccine was detected in 71% and 50% of HPV\u2010positive anal and oropharyngeal samples, respectively. The main risk factor associated with HPV detection was frequenting gay meeting places, living in large cities, and having an anal <jats:italic>Chlamydia trachomatis<\/jats:italic>\/<jats:italic>Neisseria gonorrhoeae<\/jats:italic> infection. In this cohort of highly sexually active MSM, HPV detection was highly frequent and rendered them at high risk of precancerous and cancerous lesions. Universal vaccination against HPV before sexual debut is an important public health strategy to prevent HPV\u2010associated cancers in this highly vulnerable population of HIV\u2010negative MSM.<\/jats:p>","DOI":"10.1002\/jmv.29068","type":"journal-article","created":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T06:07:34Z","timestamp":1693548454000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Anal and oropharyngeal HPV distribution in HIV\u2010negative multipartner MSM using self\u2010sampling kits for HIV and sexually transmitted infection screening"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8430-214X","authenticated-orcid":false,"given":"Jean\u2010Luc","family":"Pr\u00e9tet","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Franche\u2010Comt\u00e9 Carcinogen\u00e8se associ\u00e9e aux HPV Besan\u00e7on France"},{"name":"Centre National de 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