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There is an increasing body of evidence showing that hypoxia and hypoxia\u2010inducible factors (HIFs) play important roles in the biology of KSHV and in the pathogenesis of KSHV\u2010induced diseases. Hypoxia and HIFs can induce lytic activation of KSHV and KSHV can in turn lead to a hypoxic\u2010like state in infected cells. In this review, we describe the complex interactions between KSHV biology, the cellular responses to hypoxia, and the pathogenesis of KSHV\u2010induced diseases. We also describe how interference with HIFs can lead to decreased tumor growth and\/or death of infected cells and KSHV\u2010induced tumors. Finally, we show how these observations may lead to novel strategies for the treatment of KSHV\u2010induced diseases.<\/jats:p>","DOI":"10.1002\/jmv.29071","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:46:49Z","timestamp":1693831609000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Hypoxia and hypoxia\u2010inducible factors in Kaposi sarcoma\u2010associated herpesvirus infection and disease pathogenesis"],"prefix":"10.1002","volume":"95","author":[{"given":"David A.","family":"Davis","sequence":"first","affiliation":[{"name":"HIV and AIDS Malignancy Branch, Center for Cancer Research National Cancer Institute Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6839-7452","authenticated-orcid":false,"given":"Prabha","family":"Shrestha","sequence":"additional","affiliation":[{"name":"HIV and AIDS Malignancy 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