{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T06:02:42Z","timestamp":1776492162659,"version":"3.51.2"},"reference-count":12,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The severe acute respiratory syndrome coronavirus 2 EG.5 lineage is the latest variant under monitoring, and it is generating significant concern due to its recent upward trend in prevalence. Our aim was to gain insights into this emerging lineage and offer insights into its actual level of threat. Both genetic and structural data indicate that this novel variant presently lacks substantial evidence of having a high capacity for widespread transmission. Their viral population sizes expanded following a very mild curve and peaked several months after the earliest detected sample. Currently, neither the viral population size of EG.5 nor that of its first descendant is increasing. The genetic variability appear to be flattened, as evidenced by its relatively modest evolutionary rate (9.05\u2009\u00d7\u200910<jats:sup>\u22124<\/jats:sup> subs\/site\/year). As has been observed with numerous prior variants, attributes that might theoretically provide advantages seem to stem from genetic drift, enabling the virus to continually adjust to its host, albeit without a clear association with enhanced dangerousness. These findings further underscore the necessity for ongoing genome\u2010based monitoring, ensuring preparedness and a well\u2010documented understanding of the unfolding situation.<\/jats:p>","DOI":"10.1002\/jmv.29075","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T12:18:36Z","timestamp":1693829916000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Genetic and structural analyses reveal the low potential of the SARS\u2010CoV\u20102 EG.5 variant"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3501-714X","authenticated-orcid":false,"given":"Fabio","family":"Scarpa","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6822-4022","authenticated-orcid":false,"given":"Stefano","family":"Pascarella","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences \u201cA. Rossi Fanelli\u201d Sapienza Universit\u00e0 di Roma Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Ciccozzi","sequence":"additional","affiliation":[{"name":"Unit of Medical Statistics and Molecular Epidemiology Universit\u00e0 Campus Bio\u2010Medico di Roma Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5849-7326","authenticated-orcid":false,"given":"Marta","family":"Giovanetti","sequence":"additional","affiliation":[{"name":"Department of Science and Technology for Humans and the Environment Universit\u00e0 Campus Bio\u2010Medico di Roma Rome Italy"},{"name":"Instituto Rene Rachou, Funda\u00e7\u00e3o Oswaldo Cruz, Belo Horizonte Minas Gerais Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilenia","family":"Azzena","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari Sassari Italy"},{"name":"Department of Veterinary Medicine University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Locci","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari Sassari Italy"},{"name":"Department of Veterinary Medicine University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Casu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine University of Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-612X","authenticated-orcid":false,"given":"Pier Luigi","family":"Fiori","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Sassari Sassari Italy"},{"name":"Azienza Ospedaliera Universitaria (AOU) Sassari Sassari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriana","family":"Quaranta","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences \u201cA. 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