{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:30:47Z","timestamp":1773930647268,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T00:00:00Z","timestamp":1693958400000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Regardless of vaccination status, progression to severe coronavirus disease 2019 (COVID\u201019) is still a relevant cause of morbidity among immunocompromised patients. Despite the proven efficacy of nirmatrelvir\/ritonavir (NMV\/r), concerns remain regarding the potential for drug\u2010to\u2010drug interactions (DDIs) and the safety in this at\u2010risk population. We aimed to evaluate the clinical outcomes of immunocompromised patients treated with NMV\/r, as well as the occurrence of DDIs and treatment\u2010emergent adverse events (TEAEs). This retrospective observational study included all the patients with some form of immunosuppression and laboratory\u2010confirmed COVID\u201019 that received NMV\/r at our center from April to August 2022. The main outcome was worsening of the clinical status (increase of \u22651 point from baseline in a validated clinical progression scale) by Days +7 and +28 after the initiation of therapy. Safety outcomes included the rates of any TEAE and potentially severe DDIs.\u00a0We included 110 patients. Main causes of immunosuppression were hematological malignancy (58.2%) (mainly multiple myeloma [22.7%] and non\u2010Hodgkin lymphoma [13.6%]), active chemotherapy (30.0%) and hematopoietic stem cell transplantation (14.5%). Clinical worsening by Days +7 and +28 was observed in four (3.6%) and five patients (4.5%), respectively. Only one patient had a positive SARS\u2010CoV\u20102 polymerase chain reaction test at Day +28. At least one potentially severe DDI was observed in 56.4% of the patients. The rate of attributable TEAEs was 10.9%, although only two patients (1.8%) required premature discontinuation of NMV\/r.\u00a0Early initiation of NMV\/r therapy should be considered in immunocompromised patients with COVID\u201019, with particular attention to interacting medications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29082","type":"journal-article","created":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T12:49:50Z","timestamp":1694004590000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Nirmatrelvir\/ritonavir for the treatment of immunocompromised adult patients with early\u2010stage symptomatic COVID\u201019: A real\u2010life experience"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5087-0299","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Caso","sequence":"first","affiliation":[{"name":"Unit of Infectious Diseases Hospital 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