{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:37Z","timestamp":1753869457400,"version":"3.41.2"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T00:00:00Z","timestamp":1695081600000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) is a coronavirus belonging to the beta CoV genus, responsible for SARS in humans, which became known as COVID\u201019. The emergence of variants of this virus is related to the presence of cases of reinfection, reduced vaccine effectiveness and greater transmission of the virus. Objective: In this study, we evaluated the molecular epidemiology of SARS\u2010CoV\u20102 lineages circulating in the state of Maranh\u00e3o. This is a cross\u2010sectional and retrospective epidemiological study of genomic surveillance of SARS\u2010CoV\u20102. The study comprised of 338 genomes sequenced by the Next Generation Sequencing technique on Illumina's Miseq equipment, submitted to Global Initiative on Sharing Avian Influenza Data, 190 (56.2%) are from samples of female and 148 (43.8%) from male patients. Sequencing performed covered samples of patients aged between 1 and 108 years, with emphasis on the age groups from 30 to 39 years with 15.0% of sequenced genomes and 20 to 29 years with 12.4%. As for the distribution of sequenced genomes by health macro\u2010regions, 285 (84.3%) are from cities in the northern macro\u2010region. We evidenced the circulation of 29 lineages and sub\u2010lineages, four of which belonging to the Delta variant (AY.43, AY.99.1, AY.99.2 and AY.101 responsible for 4.5% of the genomes) and the others belonging to the Omicron variant, with emphasis on: BA.1 and sub\u2010lineages (42.8%); BA.4, BA.5 and sub\u2010lineages (5.3% and 41.1%); the sub\u2010lineages DL.1 and BQ.1 (5% and 2%). A strong genomic surveillance system allows the study of the natural history of the disease, when there is a resurgence of SARS\u2010CoV\u20102 cases.<\/jats:p>","DOI":"10.1002\/jmv.29092","type":"journal-article","created":{"date-parts":[[2023,9,19]],"date-time":"2023-09-19T07:50:08Z","timestamp":1695109808000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular epidemiology of SARS\u2010CoV\u20102 variants in circulation in the state of Maranh\u00e3o, Brazil"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7121-1417","authenticated-orcid":false,"given":"Luis Artur Ferreira","family":"de Sousa","sequence":"first","affiliation":[{"name":"Virology Laboratory, Postgraduation Program in Microbial Biology CEUMA University, UniCEUMA  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"},{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Salom\u00e3o de Sousa","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Felipe Lima","family":"Lobato","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"},{"name":"Postgraduation Program in Tropical Medicine\u2014IOC\/FIOCRUZ\u2010RJ Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hivylla Lorrana dos Santos","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Henrique dos Santos","family":"Sousa","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valdenice Ferreira dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Programme in Biodiversity and Biotechnology (BIONORTE) CEUMA University, UniCEUMA  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Ricardo Silva","family":"Nunes","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o 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da","family":"Silva","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"},{"name":"Postgraduation Program in Tropical Medicine\u2014IOC\/FIOCRUZ\u2010RJ Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo da Costa","family":"Brito","sequence":"additional","affiliation":[{"name":"Oswaldo Cruz Institute\/Central Public Health Laboratory of Maranh\u00e3o\u2014IOC\/LACEN\u2010MA S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Washington Kleber Rodrigues","family":"Lima","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Programme in Biodiversity and Biotechnology (BIONORTE) CEUMA University, UniCEUMA  S\u00e3o Lu\u00eds Maranh\u00e3o Brazil"},{"name":"UniCEUMA CEUMA University  S\u00e3o Lu\u00eds Maranh\u00e3o 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