{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:30:45Z","timestamp":1792110645540,"version":"4.4.0"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T00:00:00Z","timestamp":1694390400000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical and histopathological evidence suggest that the male reproductive system may be negatively impacted in patients with coronavirus disease (COVID\u201019). The objective of this study is to investigate the effect of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) on semen parameters by comparing semen analyses before and after COVID\u201019 diagnosis in the same patient. We retrospectively analyzed 342 semen analyses by reviewing medical records. The study included two groups of patients: (i) those who underwent two consecutive semen analyses within 6 months, one before (<jats:italic>n<\/jats:italic>\u2009=\u2009114) and one after (<jats:italic>n<\/jats:italic>\u2009=\u2009114) COVID\u201019 diagnosis, and (ii) a control group (<jats:italic>n<\/jats:italic>\u2009=\u2009114) that was age\u2010matched and did not receive a diagnosis of COVID\u201019. The study results indicated a significant decrease in semen volume, total sperm count per ejaculate, progressive motile sperm count, total motile sperm count, and normal sperm morphology after SARS\u2010CoV\u20102 infection in comparison to their respective values before the infection. Subgroup analyses showed that the duration of COVID\u201019 diagnosis (short\u2010term vs. long\u2010term) did not impact the changes in semen parameters. However, fever during the COVID\u201019 process had a negative effect on semen parameters, particularly sperm concentration, unlike in patients without fever. In conclusion, our findings suggest that SARS\u2010CoV\u20102 infection is associated with a decline in semen quality, which may potentially impact male fertility. Furthermore, it's important to note that the negative effects on semen parameters may persist in the long\u2010term. Our results also indicate that fever during active infection could be a significant risk factor that negatively affects spermatogenesis.<\/jats:p>","DOI":"10.1002\/jmv.29094","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T13:37:09Z","timestamp":1694439429000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Comparison of semen parameters in the same patients before and after diagnosis of COVID\u201019"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8332-7353","authenticated-orcid":false,"given":"Cihan","family":"Cakir","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology Uludag University School of Medicine, ART Center Bursa 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