{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:57:37Z","timestamp":1753869457952,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004716","name":"Suzhou University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004716","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>H3N2 and Omicron are common pathogens of respiratory infections in children. This study aimed to explore dynamic changes of lymphocyte subsets and the diagnostic value of CD19<jats:sup>+<\/jats:sup> B cell in children infected with influenza A and Omicron. One hundred and sixty\u2010five in\u2010patients with H3N2, 175 in\u2010patients with Omicron variant, and 50 age\u2010matched healthy children from Children's Hospital of Soochow University were included in this study. The participants underwent 13 respiratory pathogens by DNA polymerase chain reaction (PCR), sputum culture, severe acute respiratory syndrome coronavirus 2 (SARS\u2010COV\u20102) DNA PCR, routine blood, and lymphocyte subset assays within 24\u2009h of admission. The neutrophils, neutrophil\u2010to\u2010lymphocyte ratio, and monocyte\u2010to\u2010lymphocyte ratio in the H3N2 and Omicron groups were significantly higher than in the control groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). However, the lymphocytes and eosinophils in the H3N2 and Omicron groups were lower than the control groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The CD3<jats:sup>+<\/jats:sup> T cell, CD3<jats:sup>+<\/jats:sup>CD4<jats:sup>+<\/jats:sup> T cell, CD3<jats:sup>+<\/jats:sup>CD8<jats:sup>+<\/jats:sup> T cell, CD3<jats:sup>\u2212<\/jats:sup>CD19<jats:sup>+<\/jats:sup> B cell, and natural killer cell were lower in the H3N2 and Omicron groups than in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The CD3<jats:sup>\u2212<\/jats:sup>CD19<jats:sup>+<\/jats:sup> cell in the Omicron group was higher than that in the H3N2 group but lower than that in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, CD3<jats:sup>\u2212<\/jats:sup>CD19<jats:sup>+<\/jats:sup> cell had good diagnostic value for H3N2 (area under the receiver operating characteristic curve\u2009=\u20090.902, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The children with H3N2 were more likely to have lower lymphocytes than children with Omicron. Additionally, B\u2010cell count had good diagnostic value for H3N2.<\/jats:p>","DOI":"10.1002\/jmv.29097","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T05:00:15Z","timestamp":1697173215000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The CD19<sup>+<\/sup> B cell as a marker for the febrile children infected with influenza A and Omicron variant"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6222-0234","authenticated-orcid":false,"given":"Ting","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pediatric, Suzhou Municipal Hospital The Affiliated Suzhou Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Children's Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linlin","family":"Huang","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care Unit Children's Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2020.12.075"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2022.104127"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002178"},{"key":"e_1_2_11_5_1","unstructured":"Word Health Organization.2023.Weekly epidemiological update on COVID\u201019 \u2010 4 January 2023 [EB\/OL]. 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