{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:41:35Z","timestamp":1787503295809,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Anelloviridae<\/jats:italic>\n                    and Human Pegivirus 1 (HPgV\u20101) blood burden have been postulated to behave as surrogate markers for immunosuppression in transplant recipients. Here, we assessed the potential utility plasma Torque teno virus (TTV), total\n                    <jats:italic>Anelloviridae<\/jats:italic>\n                    (TAV), and HPgV\u20101 load monitoring for the identification of allogeneic hematopoietic stem cell transplantation recipients (allo\u2010HSCT) at increased risk of infectious events or acute graft versus host disease (aGvHD). In this single\u2010center, observational study, plasma TTV DNA, TAV DNA, and HPgV\u20101 RNA loads were monitored in 75 nonconsecutive allo\u2010HSCT recipients (median age, 54 years). Monitoring was conducted before at baseline or by days +30, +60, +90, +120, and +180 after transplantation. Pneumonia due to different viruses or\n                    <jats:italic>Pneumocystis jirovecii<\/jats:italic>\n                    , BK polyomavirus\u2010associated haemorrhagic cystitis (BKPyV\u2010HC), and Cytomegalovirus DNAemia were the infectious events considered in the current study. Kinetics of plasma TTV, TAV DNA, and HPgV\u20101 RNA load was comparable, with though and peak levels measured by days +30 and day +90 (+120 for HPgV\u20101). Forty patients (53%) developed one or more infectious events during the first 180 days after allo\u2010HSCT, whereas 29 patients (39%) had aGvHD (grade II\u2013IV in 18). Neither, TTV, TAV, nor HPgV\u20101 loads were predictive of overall infection or CMV DNAemia. A TTV DNA load cut\u2010off \u22654.40 log\n                    <jats:sub>10<\/jats:sub>\n                    (pretransplant) and \u22654.58 log\n                    <jats:sub>10<\/jats:sub>\n                    (baseline) copies\/mL predicted the occurrence of BKPyV\u2010HC (sensitivity \u226589%, negative predictive value, \u226596%). TTV DNA loads \u22653.38 log\n                    <jats:sub>10<\/jats:sub>\n                    by day +30 anticipated the occurrence of aGvHD (sensitivity, 90%; negative predictive value, 97%). Pretransplant HPgV\u20101 loads were significantly lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03) in patients who had aGvHD than in those who did not. Monitoring of TTV DNA or HPgV\u20101 RNA plasma levels either before or early after transplantation may be ancillary to identify allo\u2010HSCT recipients at increased risk of BKPyV\u2010HC or aGvHD.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29107","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T09:34:30Z","timestamp":1695029670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Monitoring of plasma Torque teno virus, total\n                    <i>Anelloviridae<\/i>\n                    and Human Pegivirus 1 viral load for the prediction of infectious events and acute graft versus host disease in the allogeneic hematopoietic stem cell transplantation setting"],"prefix":"10.1002","volume":"95","author":[{"given":"Lorena","family":"Forqu\u00e9","sequence":"first","affiliation":[{"name":"Microbiology Service, Clinic University Hospital INCLIVA Biomedical Research Institute Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliseo","family":"Albert","sequence":"additional","affiliation":[{"name":"Microbiology Service, Clinic University Hospital INCLIVA Biomedical Research Institute Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8533-2562","authenticated-orcid":false,"given":"Jos\u00e9 L.","family":"Pi\u00f1ana","sequence":"additional","affiliation":[{"name":"Hematology Service, Clinic University Hospital INCLIVA Biomedical Research Institute Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariadna","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Hematology Service, Clinic University Hospital INCLIVA Biomedical Research Institute Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Hernani","sequence":"additional","affiliation":[{"name":"Hematology Service, 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estela","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Microbiology Service, Clinic University Hospital INCLIVA Biomedical Research Institute Valencia Spain"},{"name":"CIBER de Enfermedades Infecciosas Instituto de Salud Carlos III Madrid 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