{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:12:42Z","timestamp":1785161562993,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T00:00:00Z","timestamp":1694995200000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Two novel assays have been developed, iTACT\u2010hepatitis B core\u2010related antigen (iTACT\u2010HBcrAg) and iTACT\u2010hepatitis B surface antigen (iTACT\u2010HBsAg) assays. We investigated the longitudinal profiles of iTACT\u2010HBcrAg\u2010 and \u2010HBsAg in patients with HBsAg seroclearance (SC) (&lt;0.05\u2009IU\/mL). This study comprises 60 HBV\u2010infected patients with HBsAg SC, 27 in chronic hepatitis\/liver cirrhosis (CH\/LC) group and 33 in inactive carrier (IC) group. Longitudinal profiles of iTACT\u2010HBcrAg and \u2010HBsAg were examined using stored serum samples. The median period from HBsAg SC to iTACT\u2010HBcrAg loss or to the last observation was longer in the CH\/LC group than the IC group (39 vs. \u22123 months, <jats:italic>p<\/jats:italic>\u2009=\u20090.004), but this tendency was not observed in that by iTACT\u2010HBsAg. Comparing the times of iTACT\u2010HBcrAg and \u2010HBsAg loss, the rate of patients who lost HBcrAg first was significantly higher in the IC group (<jats:italic>p<\/jats:italic>\u2009=\u20090.008). The cumulative incidence rate of iTACT\u2010HBcrAg loss after HBsAg SC was higher in the IC group that the CH\/LC group (<jats:italic>p<\/jats:italic>\u2009=\u20090.002). Patients in the CH\/LC group had higher rates of detectable iTACT\u2010HBcrAg than those in the IC group after HBsAg SC, suggesting that the presence of HBcrAg possibly contribute to the progression of chronic hepatitis B.<\/jats:p>","DOI":"10.1002\/jmv.29109","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T12:13:54Z","timestamp":1695039234000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Kinetics of HBcrAg and HBsAg using highly sensitive iTACT assays in chronic hepatitis B patients with HBsAg seroclearance"],"prefix":"10.1002","volume":"95","author":[{"given":"Takanori","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehisa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Center for Gastroenterology Teine\u2010Keijinkai Hospital Sapporo Hokkaido Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shintaro","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayato","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoko","family":"Kuno","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Nojiri","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Metabolism Nagoya City University Graduate School of Medical Sciences Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Kumamoto University Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,9,18]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"World Health Organization. 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