{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:25:26Z","timestamp":1777623926093,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560539"],"award-info":[{"award-number":["81560539"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81860590"],"award-info":[{"award-number":["81860590"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The association between HIV pre\u2010exposure prophylaxis (PrEP)\u00a0and the natural history of human papillomavirus (HPV)\u00a0has not been well documented. Our objective was to evaluate the impact of PrEP on the prevalence, incidence, and clearance of anal HPV among men who have sex with men (MSM). Sexually active, HIV\u2010negative MSM aged 18 years and older in Xinjiang, China since September 1, 2016, were enrolled in an ongoing observational cohort study of HPV. At baseline and every 6 months, an anal swab was taken to test for HPV and a questionnaire on sociodemographic characteristics and sexual behaviors was collected. Those who consented to receive PrEP were enrolled in an open\u2010label PrEP intervention study from November 1, 2019, to June\u00a030, 2021. This study analyzed data from participants present in the HPV cohort between November 1, 2019, and June\u00a030, 2021. We compared the prevalence, incidence, and clearance of anal HPV between men who received PrEP (PrEP\u00a0users) and those who did not (non\u2010PrEP users), and compared men before and after initiating PrEP. We calculated prevalence ratios (PRs),\u00a0incidence rate ratios (IRRs),\u00a0and clearance rate ratios (CRRs)\u00a0for both comparisons. Of the 870 participants present in the HPV cohort during the period between November 1, 2019, and June\u00a030, 2021, 859 had adequate \u03b2\u2010globin for HPV genotype testing and were included in our study. Among them, 429 were PrEP users, while 430 were non\u2010PrEP users. Median age was 32 years (interquartile range [IQR]:\u00a026\u201338). Among PrEP users, 217 were tested for anal HPV before PrEP initiation. PrEP users had lower prevalence of HPV 45, 51, and 54 (PRs:\u00a00.27 [95% CI:\u00a00.09\u20130.80], 0.42 [0.21\u20130.85], and 0.41 [0.17\u20130.99], respectively) and lower clearance of HPV 16 (CRR:\u00a00.31 [0.10\u20130.91]) compared with non\u2010PrEP users. PrEP users exhibited lower prevalence of HPV 51 (PR:\u00a00.31 [0.12\u20130.84]), lower incidence of HPV 6, 11, 16, 39 and 61 (IRRs:\u00a00.34 [0.13\u20130.90], 0.26 [0.08\u20130.87], 0.44 [0.21\u20130.91], 0.21 [0.05\u20130.93], and 0.19 [0.04\u20130.82], respectively), as well as higher clearance of HPV 52 (CRR:\u00a02.17 [1.08\u20134.35]) after PrEP initiation. PrEP use may lower the risk of HPV infection among MSM in Xinjiang, China. Our findings further extend the knowledge of the impact of PrEP on sexually transmitted infections.<\/jats:p>","DOI":"10.1002\/jmv.29112","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T07:50:58Z","timestamp":1695714658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in HPV prevalence, incidence, and clearance following the use of HIV pre\u2010exposure prophylaxis (PrEP) among MSM in Xinjiang, China: An observational cohort study"],"prefix":"10.1002","volume":"95","author":[{"given":"Tian","family":"Tian","sequence":"first","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leiwen","family":"Fu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junye","family":"Bian","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyi","family":"Zhou","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Fan","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zewen","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lirong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miaomiao","family":"Xi","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhen","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghong","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Public Health Xinjiang Medical University  Urumqi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-7576","authenticated-orcid":false,"given":"Huachun","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"School of Public Health Southwest Medical University  Luzhou China"},{"name":"Kirby Institute University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.46234\/ccdcw2021.249"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105243"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1011205"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00056-2"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506273"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(22)00138-2"},{"key":"e_1_2_10_8_1","first-page":"1265","article-title":"Expert consensus on pre\u2010exposure prophylaxis for HIV in China","volume":"26","author":"Xu J","year":"2020","journal-title":"Chin. 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