{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T21:02:17Z","timestamp":1782594137180,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T00:00:00Z","timestamp":1695686400000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The COVID\u201019 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), astonished the world and led to millions of deaths. Due to viral new mutations and immune evasion, SARS\u2010CoV\u20102 ranked first in transmission and influence. The binding affinity of human leukocyte antigen (HLA) polymorphisms to SARS\u2010CoV\u20102 might be related to immune escape, but the mechanisms remained unclear. In this study, we obtained the binding affinity of SARS\u2010CoV\u20102 strains with different HLA proteins and identified 31 risk alleles. Subsequent structural predictions identified 10 active binding sites in these HLA proteins that may promote immune evasion. Particularly, we also found that the weak binding ability with HLA class I polymorphisms could contribute to the immune evasion of Omicron. These findings suggest important implications for preventing the immune evasion of SARS\u2010CoV\u20102 and providing new insights for the vaccine design.<\/jats:p>","DOI":"10.1002\/jmv.29113","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T10:00:51Z","timestamp":1695722451000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["The binding profile of SARS\u2010CoV\u20102 with human leukocyte antigen polymorphisms reveals critical alleles involved in immune evasion"],"prefix":"10.1002","volume":"95","author":[{"given":"Yan","family":"Zhan","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacology, Xiangya Hospital Central South University  Changsha China"},{"name":"Hunan Key Laboratory of Pharmacogenetics, Institute of Clinical Pharmacology Central South University  Changsha China"},{"name":"Engineering Research Center of Applied Technology of 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