{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T06:04:03Z","timestamp":1759385043379,"version":"3.41.2"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim is to elucidate the relationship between sickle cell disorder and severe COVID\u201019. We systematically searched the required articles in three electronic databases, extracting and pooling effect sizes (ES) and 95% confidence interval (CI) from each eligible study to evaluate the effect of combined sickle cell disorder on adverse consequences in patients with COVID\u201019. This meta\u2010analysis included 21 studies. Sickle cell disease (SCD) was a risk factor for mortality (pooled ES\u2009=\u20091.70, 95% CI: 1.00\u20132.92, <jats:italic>p<\/jats:italic>\u2009=\u20090.001), hospitalization (pooled ES\u2009=\u20096.21, 95% CI: 3.60\u201310.70, <jats:italic>p<\/jats:italic>\u2009=\u20090.000) and intensive care unit (ICU) admission (pooled ES\u2009=\u20092.29, 95% CI: 1.61\u20133.24, <jats:italic>p<\/jats:italic>\u2009=\u20090.099) in COVID\u201019 patients. Patients with SCD had an increased risk of respiratory failure\/mechanical ventilation, but a statistical association was not found (pooled ES\u2009=\u20091.21, 95%CI: 0.74\u20101.98, <jats:italic>p<\/jats:italic>\u2009=\u20090.036). There was significant heterogeneity between SCD and death, hospitalization, and respiratory failure\/mechanical ventilation. The results of meta\u2010regression of SCD and hospitalization suggested that the tested variables including Area (<jats:italic>p<\/jats:italic>\u2009=\u20090.642), study design (<jats:italic>p<\/jats:italic>\u2009=\u20090.739), sample size (<jats:italic>p<\/jats:italic>\u2009=\u20090.397), proportion of males (<jats:italic>p<\/jats:italic>\u2009=\u20090.708), effect type (<jats:italic>p<\/jats:italic>\u2009=\u20090.723), whether confounding factors are adjusted (<jats:italic>p<\/jats:italic>\u2009=\u20090.606) might not be the source of heterogeneity. In addition, sickle cell trait (SCT) was significantly associated with the mortality (pooled ES\u2009=\u20091.54, 95% CI: 1.28\u20131.85, <jats:italic>p<\/jats:italic>\u2009=\u20090.771) and hospitalization (pooled ES\u2009=\u20091.20, 95% CI: 1.07\u20131.35\uff0c<jats:italic>p<\/jats:italic>\u2009=\u20090.519) in patients with COVID\u201019. But any increased risk of ICU admission\/severe (pooled ES\u2009=\u20091.24, 95% CI: 0.95\u20131.62, <jats:italic>p<\/jats:italic>\u2009=\u20090.520) and mechanical ventilation (OR\u2009=\u20091.00, 95%CI:0.59\u20101.69) in COVID\u201019 patients with SCT was not observed. Sensitivity analysis demonstrated that the results were robust. The results of the funnel plot and Egger's test did not support the existence of publication bias. Current meta\u2010analysis indicated that sickle cell disorder has a meaningful impact on COVID\u201019 progression to severe cases and associated deaths. However, further investigations and research to validate the current findings is indispensable.<\/jats:p>","DOI":"10.1002\/jmv.29120","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T09:29:18Z","timestamp":1695979758000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The association of sickle cell disorder with adverse outcomes in COVID\u201019 patients: A meta\u2010analysis"],"prefix":"10.1002","volume":"95","author":[{"given":"Tianyi","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, College of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaixin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangcai","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health Zhengzhou University Zhengzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9961-2434","authenticated-orcid":false,"given":"Rongguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, College of Public Health Zhengzhou University Zhengzhou China"},{"name":"International School of Public Health and One Health and The First Affiliated Hospital Hainan Medical University Haikou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2001316"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2020.10.004"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.12270"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103579"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.04.021"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.06.060"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.05.038"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.33213"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510865"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.10"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2009.12.022"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198803243181215"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007293"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2022.2141"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-1161"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-021-04549-1"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279222"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.7326\/M21-1375"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01627-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2022.02.048"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-021-00517-7"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-151361"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-148846"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jha2.170"},{"key":"e_1_2_10_26_1","unstructured":"DunC WalshCM BaeS et al. 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