{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T13:45:01Z","timestamp":1784036701375,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ocular manifestations have been well recognized in coronavirus disease 2019 (COVID\u201019) outbreak. Several studies have detected ocular manifestations in patients after COVID\u201019. However, little is known about the retinal and vitreal alterations in patients before and after COVID\u201019 infection. This study aimed to investigate the retinal and vitreal alterations in patients before and after contracting COVID\u201019 infection using swept\u2010source optical coherence tomography (SS\u2010OCT) and angiography (SS\u2010OCTA). A total of 38 participants (76 eyes) were enrolled and followed\u2010up 1 month after COVID\u201019 infection. Then, 26 patients (52 eyes) were evaluated 3 months after COVID\u201019 infection. Compared with the pre\u2010COVID\u201019 status, patients with 1\u2010 and 3\u2010month post\u2010COVID\u201019 statuses had significant thinning of ganglion cell and inner plexiform layer, thickening of inner nuclear layer, a decrease in the vessel density (VD) of superficial vascular complex, and an increase in the VD of deep vascular complex. Meanwhile, alteration in parameters of foveal avascular zone (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05) and hyper\u2010reflective dots in the vitreous of 27 patients (54 eyes) (71.1% vs. pre\u2010COVID\u201019, 34.2%, <jats:italic>p<\/jats:italic>\u2009=\u20090.006) were observed. These findings suggest significantly retinal and vitreal alterations occurred in patients after COVID\u201019 infection, possibly due to direct or indirect virus\u2010induced injuries. Further longitudinal studies are required to investigate the long\u2010term effects of COVID\u201019 infection on the human eyes.<\/jats:p>","DOI":"10.1002\/jmv.29168","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:47:59Z","timestamp":1697082479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of alterations in the retina and vitreous in pre\u2010 and post\u2010COVID\u201019 patients using swept\u2010source optical coherence tomography and angiography: A comparative study"],"prefix":"10.1002","volume":"95","author":[{"given":"Yuzhu","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Department of Ophthalmology and Research Laboratory of Ophthalmology, West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Department of Ophthalmology, 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