{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T04:40:55Z","timestamp":1784263255450,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T00:00:00Z","timestamp":1698192000000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Human mpox is occurring worldwide, however, evidence from the Asian Pacific Region is limited.\u00a0In this multicenter cross\u2010sectional study, information of confirmed mpox cases diagnosed between June 1 and July 31, 2023 in China. Information included demographic and epidemiological characteristics, and clinical manifestations, laboratory results, and mental health status of mpox cases. A total of 115 confirmed mpox cases were enrolled. All cases were men.\u00a0A total of 102 (90.3%) identified as homosexual. The median age was 31.0 years (interquartile range 27.0\u201336.5). A total of 65 (56.5%) were HIV\u2010positive, of whom 92.3% were receiving antiretroviral therapy (ART). A total of 19\/39 (40.4%) had a CD4 cell count &lt;500\u2009cells\/\u03bcL. Systemic features such as fever (73.0%), lymphadenopathies (49.6%), and myalgia (28.7%) were commonly observed. Skin lesions were present in all participants: 49.6% in the genital area and 27.0% in the perianal area. Vesicular rash (78.3%) and papular rash (44.3%) were the most common lesion morphologies. People living with HIV were more likely to have anxiety than those living without HIV.\u00a0The majority of mpox cases had primary genital lesions and sexual activities before diagnosis, which supports the likelihood of sexual contact transmission. Guidelines on hospitalization and isolation protocols for mpox patients necessitate further confirmation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29198","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T06:10:42Z","timestamp":1698300642000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Epidemiological characteristics, clinical manifestations, and mental health status of human mpox cases: A multicenter cross\u2010sectional study in China"],"prefix":"10.1002","volume":"95","author":[{"given":"Leiwen","family":"Fu","sequence":"first","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3713-0488","authenticated-orcid":false,"given":"Bingyi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang District Center for Disease Prevention and Control  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuqing","family":"Yang","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7409-8528","authenticated-orcid":false,"given":"Zhongsi","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fifth Affiliated Hospital, Sun Yat\u2010sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Tianjin Second People's Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojun","family":"Meng","sequence":"additional","affiliation":[{"name":"Wuxi Center for Disease Control and Prevention Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Tianjin Second People's Hospital  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Qi","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang District Center for Disease Prevention and Control  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Qingdao Sixth People's Hospital  Qingdao Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0582-5255","authenticated-orcid":false,"given":"Weijie","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenming","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang District Center for Disease Prevention and Control  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang District Center for Disease Prevention and Control  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanlong","family":"Lin","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanxian","family":"Cao","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine The First Affiliated Hospital of the University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Fifth Affiliated Hospital, Sun Yat\u2010sen University  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weibo","family":"Wu","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Gao","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine The First Affiliated Hospital of the University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Lv","sequence":"additional","affiliation":[{"name":"National Center for AIDS\/Sexually Transmitted Disease Control and Prevention The Chinese Center for Disease Control and Prevention  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhou","family":"Lu","sequence":"additional","affiliation":[{"name":"National Clinical Research Centre for Infectious Diseases, The Third People's Hospital of Shenzhen and The Second Affiliated Hospital of Southern University of Science and Technology  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8161-7576","authenticated-orcid":false,"given":"Huachun","family":"Zou","sequence":"additional","affiliation":[{"name":"School of Public Health Fudan University  Shanghai China"},{"name":"School of Public Health Southwest Medical University  Luzhou China"},{"name":"Kirby Institute University of New South Wales  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,10,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2207323"},{"issue":"5","key":"e_1_2_10_3_1","first-page":"593","article-title":"A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo","volume":"46","author":"Ladnyj ID","year":"1972","journal-title":"Bull World Health Organ"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.15-0095"},{"key":"e_1_2_10_5_1","unstructured":"World Health Organization.Multi\u2010Country Monkeypox Outbreak: Situation Update. Accessed\u00a0August 2 2023.\u00a0https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2022-DON393"},{"key":"e_1_2_10_6_1","unstructured":"World Health Organization.Multi\u2010Country Outbreak of mpox External Situation Report #26 \u2013 14 July 2023. Accessed August 2 2023.\u00a0https:\/\/www.who.int\/publications\/m\/item\/multi-country-outbreak-of-mpox--external-situation-report--26---14-july-2023"},{"key":"e_1_2_10_7_1","unstructured":"World Health Organization.Fifth Meeting of the International Health Regulations (2005) (IHR) Emergency Committee on the Multi\u2010Country Outbreak of mpox (monkeypox). Accessed\u00a0August 2 2023.\u00a0https:\/\/www.who.int\/news\/item\/11-05-2023-fifth-meeting-of-the-international-health-regulations-(2005)-(ihr)-emergency-committee-on-the-multi-country-outbreak-of-monkeypox-(mpox)"},{"key":"e_1_2_10_8_1","unstructured":"CHINADAILY.106 Monkeypox Cases Reported. Accessed August 2 2023.\u00a0https:\/\/www.chinadaily.com.cn\/a\/202307\/17\/WS64b48ee2a31035260b816bc0.html"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0010141"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12010146"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00198-5"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00806-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa143"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7136a1"},{"issue":"23","key":"e_1_2_10_15_1","article-title":"Clinical characteristics and predictors of human mpox outcome during the 2022 outbreak in Nigeria: a cohort study","volume":"1473","author":"Ogoina D","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.28713"},{"key":"e_1_2_10_17_1","article-title":"Mental health implications of monkeypox: an urgent need for action","volume":"82","author":"Aroyewun TF","year":"2022","journal-title":"Ann Med Surg (Lond)"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2022.106943"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijregi.2022.04.004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/lgbt.2022.0281"},{"key":"e_1_2_10_21_1","unstructured":"CHINADAILY.Two Cases of Monkeypox Isolated in Beijing. Accessed August 2 2023.\u00a0https:\/\/www.chinadaily.com.cn\/a\/202306\/07\/WS647fe7a9a31033ad3f7bae86.html"},{"key":"e_1_2_10_22_1","unstructured":"China Center for Disease Control and Prevention.Notice on the Issuance of the Program for the Prevention and Control of Monkeypox. Accessed August 3 \u00a02023.https:\/\/www.chinacdc.cn\/jkzt\/crb\/qt\/szkb_13037\/jswj\/202307\/t20230727_268170.html"},{"key":"e_1_2_10_23_1","unstructured":"Guidelines for the Diagnosis and Treatment of Mpox (2022 edition). Accessed August 3 2023.\u00a0http:\/\/www.nhc.gov.cn\/yjb\/s3577\/202207\/acd6016aaca543e29c16deb9b5ea3303.shtml"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01436-2"},{"key":"e_1_2_10_25_1","unstructured":"DixonCWJ ChurchillA;London:1962. Smallpox."},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2021.10.020"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2021.1996152"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.genhosppsych.2014.05.021"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2015.11.019"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.7478"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjo.2021.1008"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2196\/22596"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/1745017901006010101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2196\/24623"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.773106"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.54724\/lc.2022.e1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00228-6"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7132e3"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22-2457"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00259-2"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jtm\/taad111"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.36.2200620"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00651-X"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2022.27.28.2200503"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00513-8"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180309105519"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofv040"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214229"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.2934"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(19)30343-1"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0173928"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.92.3.378"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-015-1164-1"},{"key":"e_1_2_10_54_1","article-title":"Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series","volume":"378","author":"Patel A","year":"2022","journal-title":"BMJ (Clinical research ed)"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/20008198.2022.2055294"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhin.2010.04.027"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s44197-022-00070-4"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/nhs.12878"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-030371"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29198","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,2]],"date-time":"2024-08-02T12:31:40Z","timestamp":1722601900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29198"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":58,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jmv.29198"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29198","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"2023-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29198"}}