{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T07:53:00Z","timestamp":1781250780850,"version":"3.54.1"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T00:00:00Z","timestamp":1699228800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","award":["CMRPG1J0081"],"award-info":[{"award-number":["CMRPG1J0081"]}],"id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A complete investigation of the clinical outcomes after treatment cessation in HBeAg\u2010positive patients with HBeAg loss is limited. We retrospectively recruited 242 HBeAg\u2010positive patients with HBeAg loss after a median duration of 37.2 months with tenofovir (TDF, <jats:italic>n<\/jats:italic>\u2009=\u200977) or entecavir (ETV, <jats:italic>n<\/jats:italic>\u2009=\u2009165) treatment. There were 77 (31.8%) patients with sustained virological remission (SVR), 85 (35.1%) with HBeAg\u2010reversion virological relapse, 80 (33.1%) with HBeAg\u2010negative virological relapse after treatment cessation, and 23 (9.5%) with HBsAg loss. Clinical data at baseline, on\u2010treatment and during off\u2010treatment follow\u2010up were analyzed. The 3\u2010year cumulative incidences of overall, HBeAg\u2010reversion and HBeAg\u2010negative virological relapse were 70.2%, 54%, and 53.5%, respectively. The common factors associated with HBeAg\u2010reversion and HBeAg\u2010negative virological relapse were tenofovir treatment (hazard ratio [HR]\u2009=\u20095.411, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; HR\u2009=\u20092.066, <jats:italic>p<\/jats:italic>\u2009=\u20090.006, respectively) and HBsAg at end of treatment (EOT) (HR\u2009=\u20091.461, <jats:italic>p<\/jats:italic>\u2009=\u20090.001; HR\u2009=\u20091.303, <jats:italic>p<\/jats:italic>\u2009=\u20090.019, respectively). The 5\u2010year cumulative incidence of HBsAg loss in SVR patients was 13.7% and EOT HBsAg was the only associated factor (HR\u2009=\u20090.524, <jats:italic>p<\/jats:italic>\u2009=\u20090.024). Compared to that of ETV\u2010treated patients, TDF\u2010treated patients had a significantly higher 3\u2010year cumulative incidence of virological relapse (87.3% vs. 62.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), earlier HBeAg\u2010reversion virological relapse (2.9 vs. 7.8 months, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), a higher rate of HBeAg\u2010reversion virological relapse (53.2% vs. 26.7%) and a lower SVR rate (15.6% vs. 39.4%) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In summary, the clinical outcomes after treatment cessation in HBeAg\u2010positive patients with HBeAg loss were composed of HBeAg\u2010reversion virological relapse, HBeAg\u2010negative virological relapse and SVR. TDF was significantly associated with off\u2010treatment virological relapse. EOT HBsAg plays an important role in HBsAg loss among SVR patients and posttreatment virological relapse.<\/jats:p>","DOI":"10.1002\/jmv.29213","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T12:30:50Z","timestamp":1698237050000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Higher HBeAg\u2010reversion virological relapse and lower sustained remission after treatment cessation in tenofovir\u2010treated HBeAg\u2010positive patients"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7810-7145","authenticated-orcid":false,"given":"Yi\u2010Cheng","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital  Taoyuan City Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan City Taiwan"},{"name":"School of Medicine National Tsing Hua University  Hsinchu Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Wei","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital  Taoyuan City Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong\u2010Nan","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital  Taoyuan City Taiwan"},{"name":"College of Medicine Chang Gung University  Taoyuan City 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