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Imiquimod is a topical agent that acts as a Toll\u2010like receptor 7\/8 agonist, stimulating the innate and adaptive immune system to exert antitumor and antiviral effects. It has been approved for the treatment of various skin conditions, however, its efficacy and safety in the management of HPV\u2010related\u2010neoplasms of the lower genital tract, such as vulvar, vaginal, and cervical neoplasia, are still under investigation. 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