{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T14:55:33Z","timestamp":1773240933514,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T00:00:00Z","timestamp":1701043200000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Avian influenza A viruses (IAVs) that cross the species barrier to infect humans have the potential to initiate a new pandemic. However, the host factors influencing avian IAV infection remain poorly understood. To address this knowledge gap, we conducted a two\u2010sample Mendelian randomization (MR) analysis by integrating our in\u2010house genome\u2010wide association study (GWAS) of avian IAV H7N9 susceptibility (with 217 cases and 116 controls) with the largest GWAS of serum IgA levels to date (sample size 41\u2009263). Using the inverse\u2010variance weighted (IVW) method, we discovered that genetically decreased serum IgA levels were associated with an increased risk of H7N9 infection (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22122.528, 95% confidence interval [CI]: \u22124.572 to \u22120.484; <jats:italic>p<\/jats:italic>\u2009=\u20090.015). Consistent results were obtained from three other MR methods, including robust IVW estimation (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22122.506, 95% CI: \u22124.109 to \u22120.902; <jats:italic>p<\/jats:italic>\u2009=\u20090.002), generalized summary\u2010data\u2010based MR (GSMR) (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22122.238, 95% CI: \u22124.106 to \u22120.602; <jats:italic>p<\/jats:italic>\u2009=\u20090.019), and MR\u2010pleiotropy residual sum and outlier (MR\u2010PRESSO) (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009\u22122.528, 95% CI: \u22124.396 to \u22120.892; <jats:italic>p<\/jats:italic>\u2009=\u20090.026). In conclusion, our analysis provided compelling evidence support a causal relationship between genetically predicted serum IgA levels and avian IAV H7N9 susceptibility.<\/jats:p>","DOI":"10.1002\/jmv.29266","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T23:47:43Z","timestamp":1701128863000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Mendelian randomization study on the causal effect of serum IgA levels on H7N9 avian influenza A virus susceptibility"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7517-9867","authenticated-orcid":false,"given":"Qijun","family":"Liao","sequence":"first","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"},{"name":"BGI Research  Shenzhen People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Shen","sequence":"additional","affiliation":[{"name":"BGI Research  Shenzhen People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-476X","authenticated-orcid":false,"given":"Yongkun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology Shenzhen University Health Science Center  Shenzhen People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-0916","authenticated-orcid":false,"given":"Yuelong","family":"Shu","sequence":"additional","affiliation":[{"name":"School of Public Health (Shenzhen) Shenzhen Campus of Sun Yat\u2010Sen University  Shenzhen People's Republic of China"},{"name":"Institute of Pathogen Biology Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,11,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldz036"},{"key":"e_1_2_10_3_1","unstructured":"Food and Agriculture Organization of the United Nations (FAO).\u00a0Avian influenza A (H7N9) virus situation update.2022https:\/\/www.fao.org\/animal-health\/situation-updates\/avian-influenza-A(H7N9)-virus\/en"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011450"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12379"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","unstructured":"ZhuW ZhouJ LiZ et al. 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