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Establishing a causal link between COVID\u201019 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID\u201019 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID\u201019 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID\u201019 and CP. A direct causal relationship between genetically predicted COVID\u201019 phenotypes and pancreatitis risk cannot be established. 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