{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T20:27:57Z","timestamp":1769977677072,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,12]],"date-time":"2023-12-12T00:00:00Z","timestamp":1702339200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>To investigate the molecular epidemiological characteristics and genetic variations of human adenovirus (HAdV) in acute respiratory tract infections in Beijing. Whole\u2010genome sequencing and phylogenetic analyses were performed for 83 strains of HAdV with different types in Beijing from 2014 to 2019. The clinical characteristics of HAdV infection were analyzed statistically. HAdV\u2010B was divided into four genotypes, including B3 (<jats:italic>n<\/jats:italic>\u2009=\u200911), B7 (<jats:italic>n<\/jats:italic>\u2009=\u200913), B14 (<jats:italic>n<\/jats:italic>\u2009=\u20094), and B55 (<jats:italic>n<\/jats:italic>\u2009=\u20092). HAdV\u2010C was divided into three genotypes, including C1 (<jats:italic>n<\/jats:italic>\u2009=\u200914), C2 (<jats:italic>n<\/jats:italic>\u2009=\u200913), and C5 (<jats:italic>n<\/jats:italic>\u2009=\u200910). In HAdV\u2010C, nine recombinant adenovirus strains were identified in type 1, and seven recombinant strains were found in type 2. In type 1, we found three newly emerged intraspecific recombinant strains (A47, A48, and A52) collected in 2017, 2018, and 2019, respectively. In addition, the previously reported recombinant strains of HAdV\u2010C1 showed more severe disease than other strains of HAdV\u2010C, causing severe community\u2010acquired pneumonia in both the elderly and children. Continuous population\u2010wide molecular epidemiological surveillance of HAdV is essential for the prevention and control of respiratory infectious diseases.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29284","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T05:05:03Z","timestamp":1702443903000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genome sequencing reveals molecular epidemiological characteristics and new recombinations of adenovirus in Beijing, China, 2014\u22122019"],"prefix":"10.1002","volume":"95","author":[{"given":"Maozhong","family":"Li","sequence":"first","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"},{"name":"Beijing Research Center for Respiratory Infectious Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Kang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"},{"name":"Beijing Research Center for Respiratory Infectious Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Gong","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"},{"name":"Beijing Research Center for Respiratory Infectious Diseases  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Luo","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuejiao","family":"Guan","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yigang","family":"Tong","sequence":"additional","affiliation":[{"name":"Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology Beijing University of Chemical Technology  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7453-3470","authenticated-orcid":false,"given":"Fang","family":"Huang","sequence":"additional","affiliation":[{"name":"Beijing Center for Disease Control and Prevention\/Beijing Academy for Preventive Medicine\/Beijing Institute of Tuberculosis Control Research and Prevention Institute for immunization and prevention  Beijing China"},{"name":"Beijing Research Center for Respiratory Infectious Diseases  Beijing China"},{"name":"College of Public Health Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6639a2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1283287"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/jgv.0.000947"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-092818-015550"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00116-13"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584923"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2206.151898"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1086\/342573"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00046.2018"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01694-09"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1098\/rspb.2015.0488"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.12.053"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010080"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46228-2"},{"key":"e_1_2_9_16_1","first-page":"208","article-title":"Author correction: genomic analysis of a large set of currently\u2010and historically\u2010important human adenovirus pathogens","volume":"7","author":"Ismail AM","year":"2018","journal-title":"Emerg Microbes Infect"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15336-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1186"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.12232"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121375"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv033"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkf436"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msaa015"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.152-160.1999"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2022.07.015"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11020129"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37756-4"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2022.10.001"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.104035"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep23014"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2402.171407"},{"key":"e_1_2_9_33_1","first-page":"566","article-title":"Adenoviral infections in Singapore: should new antiviral therapies and vaccines be adopted?","volume":"221","author":"Coleman KK","year":"2020","journal-title":"J Infect Dis"},{"key":"e_1_2_9_34_1","first-page":"177","article-title":"Molecular characterization of human adenoviruses isolated in Italy","volume":"29","author":"La Rosa G","year":"2006","journal-title":"New Microbiol"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.10.052"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0232092"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07365"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25333"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37216"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T15:01:34Z","timestamp":1715007694000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":38,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/jmv.29284"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29284","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"value":"0146-6615","type":"print"},{"value":"1096-9071","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"2023-06-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29284"}}