{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T22:33:45Z","timestamp":1790980425542,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Human papillomaviruses (HPV) of the genus <jats:italic>Betapapillomavirus<\/jats:italic> can infect both cutaneous and mucosal sites, but research on their natural history at mucosal sites remains scarce. We examined the risk factors and co\u2010detection patterns of HPVs of the <jats:italic>Betapapillomavirus<\/jats:italic> and <jats:italic>Alphapapillomavirus<\/jats:italic> genera in cervical samples of the Ludwig\u2010McGill cohort study. We assessed a subset of 505 women from the Ludwig\u2010McGill cohort study from S\u00e3o Paulo, Brazil. Cervical samples over the first year of follow\u2010up were tested for DNA of over 40 alphapapillomavirus types and 43 betapapillomavirus types using a type\u2010specific multiplex genotyping polymerase chain reaction assay. We assessed the risk factors for prevalent and incident betapapillomavirus type detection, and whether types were detected more frequently together than expected assuming independence using permutation tests, logistic regression, and Cox regression. We observed significant within\u2010genus clustering but not cross\u2010genus clustering. Multiple betapapillomavirus types were co\u2010detected in the same sample 2.24 (95% confidence interval [CI]: 1.65\u20133.29) times more frequently than expected. Conversely, co\u2010detections of alphapapillomavirus and betapapillomavirus types in the same sample occurred only 0.64 (95% CI: 0.51\u20130.83) times as often as expected under independence. In prospective analyses, positivity to one HPV genus was associated with a nonsignificant lower incidence of detection of types in the other genus. Lifetime number of sex partners and new sex partner acquisition were associated with lower risks of prevalent and incident betapapillomavirus detection. Betapapillomaviruses are commonly found in the cervicovaginal tract. Results suggest potentially different mechanisms of transmission for betapapillomavirus genital infections other than vaginal sex.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29288","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T17:29:34Z","timestamp":1701883774000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Betapapillomavirus natural history and co\u2010detection with alphapapillomavirus in cervical samples of adult women"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-3564","authenticated-orcid":false,"given":"Tal\u00eda","family":"Malag\u00f3n","sequence":"first","affiliation":[{"name":"Gerald Bronfman Department of Oncology, Division of Cancer Epidemiology McGill University Montr\u00e9al Canada"},{"name":"St Mary's Research Centre Montreal West Island Integrated University Health and Social Services Centre Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-533X","authenticated-orcid":false,"given":"Aline Lopes","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Oncology Instituto do Cancer do Estado de Sao Paulo ICESP: Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP HC S\u00e3o Paulo Brazil"},{"name":"Comprehensive Center for Precision Oncology Universidade de Sao Paulo, S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-9007","authenticated-orcid":false,"given":"Emily","family":"Montosa Nunes","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Oncology Instituto do Cancer do Estado de Sao Paulo ICESP: Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP HC S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7088-337X","authenticated-orcid":false,"given":"Tarik","family":"Gheit","sequence":"additional","affiliation":[{"name":"Epigenomics and Mechanisms Branch International Agency for Cancer Research (IARC) Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5190-0370","authenticated-orcid":false,"given":"Mariam","family":"El\u2010Zein","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology, Division of Cancer Epidemiology McGill University Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4074-2335","authenticated-orcid":false,"given":"Luisa L.","family":"Villa","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Oncology Instituto do Cancer do Estado de Sao Paulo ICESP: Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP HC S\u00e3o Paulo Brazil"},{"name":"Comprehensive Center for Precision Oncology Universidade de Sao Paulo, S\u00e3o Paulo  Brazil"},{"name":"Department of Radiology and Oncology, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4409-8084","authenticated-orcid":false,"given":"Eduardo L.","family":"Franco","sequence":"additional","affiliation":[{"name":"Gerald Bronfman Department of Oncology, Division of Cancer Epidemiology McGill University Montr\u00e9al Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-5818","authenticated-orcid":false,"given":"Laura","family":"Sichero","sequence":"additional","affiliation":[{"name":"Center for Translational Research in Oncology Instituto do Cancer do Estado de Sao Paulo ICESP: Hospital das Cl\u00ednicas da Faculdade de Medicina da Universidade de S\u00e3o Paulo FMUSP HC S\u00e3o Paulo Brazil"},{"name":"Comprehensive Center for Precision Oncology Universidade de Sao Paulo, S\u00e3o Paulo  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_10_2_1","first-page":"1","article-title":"Biological agents. volume 100 B. 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