{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:41:04Z","timestamp":1791240064323,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","award":["21\u2010B\u20100437"],"award-info":[{"award-number":["21\u2010B\u20100437"]}],"id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010363","name":"Minister Erna Hamiltons Legat for Videnskab og Kunst","doi-asserted-by":"publisher","award":["60988"],"award-info":[{"award-number":["60988"]}],"id":[{"id":"10.13039\/501100010363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010352","name":"Helen Rudes Fond","doi-asserted-by":"publisher","award":["24\u20102022"],"award-info":[{"award-number":["24\u20102022"]}],"id":[{"id":"10.13039\/501100010352","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Ramsay Hunt syndrome (RHS) is a manifestation of reactivated varicella\u2010zoster virus (VZV) from the geniculate ganglion. Data on clinical features and outcomes of patients with RHS and concurrent VZV meningitis (henceforth RHS meningitis) are limited. Thus, we conducted a nationwide population\u2010based cohort study of all adults hospitalized for RHS meningitis at the departments of infectious diseases in Denmark from 2015 to 2020. Patients with VZV meningitis without cranial nerve palsies were included for comparison. In total, 37 patients with RHS meningitis (mean annual incidence: 1.6\/1\u2009000\u2009000 adults) and 162 with VZV meningitis without cranial nerve palsies were included. In RHS meningitis, the median age was 52 years (interquartile range: 35\u201364), and in addition to peripheral facial nerve palsy (100%), dizziness (46%), and hearing loss (35%) were common symptoms. The triad of headache, neck stiffness, and photophobia\/hyperacusis was less common in RHS meningitis than in VZV meningitis without cranial nerve palsies (0\/27 [0%] vs. 24\/143 [17%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.02). At 30 days after discharge, 18\/36 (50%) patients with RHS meningitis had persistent peripheral facial nerve palsy, with no statistically significant difference between those treated with and without adjuvant glucocorticoids (6\/16 [38%] vs. 12\/20 [60%]; <jats:italic>p<\/jats:italic>\u2009=\u20090.18). Additional sequelae of RHS meningitis included dizziness (29%), neuralgia (14%), tinnitus\/hyperacusis (11%), hearing loss (9%), headache (9%), fatigue (6%), and concentration difficulties (3%). In conclusion, clinical features and outcomes of RHS meningitis were primarily related to cranial neuropathies.<\/jats:p>","DOI":"10.1002\/jmv.29291","type":"journal-article","created":{"date-parts":[[2023,12,7]],"date-time":"2023-12-07T23:39:33Z","timestamp":1701992373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ramsay Hunt syndrome and concurrent varicella\u2010zoster virus meningitis in Denmark: A nationwide cohort study"],"prefix":"10.1002","volume":"95","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-9352-6093","authenticated-orcid":false,"given":"Pelle T.","family":"Petersen","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Infectious Diseases Nordsj\u00e6llands Hospital Hiller\u00f8d Denmark"},{"name":"Faculty of Health and Medical Sciences University of Copenhagen Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Bodilsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha P. G.","family":"Jepsen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Infectious Diseases Nordsj\u00e6llands Hospital Hiller\u00f8d Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lykke","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merete","family":"Storgaard","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jannik","family":"Helweg\u2010Larsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lothar","family":"Wiese","sequence":"additional","affiliation":[{"name":"Department of Medicine Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitte R.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Hvidovre Hospital  Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans R.","family":"L\u00fcttichau","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Herlev Hospital  Herlev Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian \u00d8.","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Hvidovre Hospital Hvidovre Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Aalborg University Hospital  Aalborg Denmark"},{"name":"Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian T.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Department of Medicine Zealand University Hospital  Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Danish Study Group of Infections of the Brain (DASGIB)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-190702000-00001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.71.2.149"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004150050328"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09387-w"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-020-00872-x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S326461"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit458"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad089"},{"key":"e_1_2_11_10_1","unstructured":"Statistics Denmark [Internet]. 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