{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:51:06Z","timestamp":1788187866476,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T00:00:00Z","timestamp":1703635200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>People living with human immunodeficiency virus (HIV) are the individuals most affected by the current Monkeypox virus outbreak that was first announced in May 2022. Here we report Pan\u2010pox\u2010specific T\u2010cell responses in a cohort of HIV\u20101\u2010infected individuals after receiving the nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination was safe without major side effects. Dose\u2010sparing i.d. vaccination was superior to s.c. vaccination and promoted T\u2010cell polyfunctionality, and the expression of the gut\u2010homing marker \u03b14\u03b27 integrin on lymphocytes. HIV\u20101\u2010infected individuals with CD4 T\u2010cell counts \u2264500\/mm<jats:sup>3<\/jats:sup> blood required at least a booster vaccination to exhibit efficient virus\u2010specific T\u2010cell responses. The magnitude of the Th1 response after this booster directly correlated with the CD4 T\u2010cell count of the vaccinees. Further studies with a larger number of participants are warranted to confirm and expand our observations.<\/jats:p>","DOI":"10.1002\/jmv.29317","type":"journal-article","created":{"date-parts":[[2023,12,27]],"date-time":"2023-12-27T19:00:23Z","timestamp":1703703623000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pan\u2010pox\u2010specific T\u2010cell responses in HIV\u20101\u2010infected individuals after JYNNEOS vaccination"],"prefix":"10.1002","volume":"96","author":[{"given":"Marta","family":"Sistere\u0301\u2010Oro\u0301","sequence":"first","affiliation":[{"name":"Infection Biology Laboratory, Department of Medicine and Life Sciences Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Du","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana D. J.","family":"Wortmann","sequence":"additional","affiliation":[{"name":"Infection Biology Laboratory, Department of Medicine and Life Sciences Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina D.","family":"Filippi","sequence":"additional","affiliation":[{"name":"Infection Biology Laboratory, Department of Medicine and Life Sciences Universitat Pompeu Fabra (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Ca\u00f1as\u2010Ruano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Arrieta\u2010Aldea","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agust\u00edn","family":"Marcos\u2010Blanco","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital del Mar Research Institute  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Castells","sequence":"additional","affiliation":[{"name":"Preventive Medicine Unit Hospital del Mar Research Institute Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Grau","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hospital del Mar Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Garc\u00eda\u2010Giralt","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Perez\u2010Zsolt","sequence":"additional","affiliation":[{"name":"IrsiCaixa, AIDS Research Institute Can Ruti Campus, UAB Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6720-1577","authenticated-orcid":false,"given":"Rytis","family":"Boreika","sequence":"additional","affiliation":[{"name":"IrsiCaixa, AIDS Research Institute Can Ruti Campus, UAB Badalona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Izquierdo\u2010Useros","sequence":"additional","affiliation":[{"name":"IrsiCaixa, AIDS Research Institute Can Ruti Campus, UAB Badalona Spain"},{"name":"Germans Trias i Pujol Research Institute (IGTP)  Badalona Spain"},{"name":"CIBER Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-9161","authenticated-orcid":false,"given":"Robert","family":"G\u00fcerri\u2010Fernandez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit Hospital del Mar Research Institute  Barcelona Spain"},{"name":"CIBER Enfermedades Infecciosas (CIBERINFEC) Instituto de Salud Carlos III Madrid Spain"},{"name":"Department of Medicine and Life Sciences (MELIS) Universitat Pompeu Fabra, Barcelona (UPF) Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0214-6348","authenticated-orcid":false,"given":"Andreas","family":"Meyerhans","sequence":"additional","affiliation":[{"name":"Infection Biology Laboratory, Department of Medicine and Life Sciences Universitat Pompeu Fabra (UPF) Barcelona Spain"},{"name":"ICREA Catalan Institution for Research and Advanced Studies Pg. Llui\u0301s Companys 23 Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(22)00291-9"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2022.102855"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-022-01421-8"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2022.11.003"},{"key":"e_1_2_8_6_1","unstructured":"World Health Organization. Vaccines and immunization for Monkeypox. Published June 14 2022. 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