{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:26:31Z","timestamp":1758709591150,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009950","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005795","name":"Chang Gung Memorial Hospital, Linkou","doi-asserted-by":"publisher","award":["CMRPG3K2091\u20102"],"award-info":[{"award-number":["CMRPG3K2091\u20102"]}],"id":[{"id":"10.13039\/501100005795","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Enteroviruses (EVs), single\u2010stranded, positive\u2010sense RNA viruses, can be classified into four species (A\u2212D), which have previously been linked to a diverse range of disease manifestations and infections affecting the central nervous system. In the <jats:italic>Enterovirus<\/jats:italic> species B (EV\u2010B), Echovirus type 11 (E11) has been observed to occasionally circulate in Taiwan, which was responsible for an epidemic of enterovirus infections in 2018. Here, 48 clinical specimens isolated in 2003, 2004, 2009, and 2018 were collected for the high\u2010throughput sequencing. Notably, we identified 2018 Taiwanese strains having potential recombinations in the 3D gene, as well as one 2003 strain having a double recombination with E6 and Coxsackievirus B5 in the P2 and P3 regions, respectively. Additionally, one amino acid signature mutated from the Histidine (H) in throat swab specimens to the Tyrosine (Y) in cerebral spinal fluid specimens was detected at position 1496 (or 57) of the genomic coordinate (or 3A gene) to further demonstrate intra\u2010host evolution in different organs. In conclusion, this study identifies potential intertypic recombination events and an intra\u2010host signature mutation in E11 strains, isolated during a 2018 neurological disease outbreak in Taiwan, contributing to our understanding of its evolution and pathogenesis.<\/jats:p>","DOI":"10.1002\/jmv.29323","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T07:52:23Z","timestamp":1704181943000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Novel intertypic recombination of Echovirus 11 in the <i>Enterovirus<\/i> species B"],"prefix":"10.1002","volume":"96","author":[{"given":"Yu\u2010Nong","family":"Gong","sequence":"first","affiliation":[{"name":"Research Center for Emerging Viral Infections, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"International Master Degree Program for Molecular Medicine in Emerging Viral Infections, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"National Institute of Infectious Diseases and Vaccinology National Health Research Institutes  Zhunan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Medical Biotechnology and Laboratory Science, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Ching","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Infectious Diseases Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi\u2010Chun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yhu\u2010Chering","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Pediatric Infectious Diseases Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"School of Medicine, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo\u2010Chien","family":"Tsao","sequence":"additional","affiliation":[{"name":"Research Center for Emerging Viral Infections, College of Medicine Chang Gung University  Taoyuan Taiwan"},{"name":"Department of Laboratory Medicine Linkou Chang Gung Memorial Hospital  Taoyuan Taiwan"},{"name":"Department of Medical Biotechnology and Laboratory Science, College of Medicine Chang Gung University  Taoyuan Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-019-04520-6"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06112-9"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46870-w"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.12.3928-3933.1999"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/2329048X17751526"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2019.09.012"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/SQB.1962.027.001.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.19469-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81264-0"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.04.026"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-015-2496-x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ve\/veaa029"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-012-0340-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu170"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/cmb.2012.0021"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151495"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/mst010"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btu033"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-1702(02)00291-5"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(00)02024-2"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.152-160.1999"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909233411301"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01020-07"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00897-21"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(94)00104-K"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.074682-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.inf.0000237798.07462.32"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30238-4"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T23:10:28Z","timestamp":1743894628000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/jmv.29323"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29323","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"2023-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29323"}}