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In this research, a total of 1933 neonates and 2502 pregnant women were enrolled, and their sera for IgG and IgM antibodies against rubella were tested by chemiluminescence assay. Of 1933 neonates' sera tested, the seropositive of rubella IgG was 68.7%. The seroprevalence of rubella IgM in neonates was 0.4%. 30.9% of neonates had negative results for IgG and IgM antibodies. Two thousand five hundred and two pregnant women participated in the serosurvey, and 79.3% were rubella IgG positive. Rubella IgG seropositivity in pregnant women differed by age and number of births. 0.8% of the pregnant women had positive results for IgM against the rubella virus. The seronegative of rubella IgG and IgM antibodies in pregnant women was 19.8%. Due to the negative rubella\u2010specific IgG antibody, many neonates remain at risk of rubella virus infection. Rubella virus continues to spread since some neonates and pregnant women with rubella\u2010specific IgM antibody positive have been detected. Rubella vaccination may be introduced for childbearing\u2010age women to increase immunity levels against rubella with periodic sero\u2010surveillance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29340","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T09:29:55Z","timestamp":1703237395000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Seroepidemiology study of rubella virus antibodies among neonates and pregnant women at hospitals in Henan province, China"],"prefix":"10.1002","volume":"95","author":[{"given":"Xiangpeng","family":"Wang","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Immunology and Targeted Drugs, School of Medical Technology Xinxiang Medical University Xinxiang China"},{"name":"Xinxiang Key Laboratory of Tumor Microenvironment and Immunotherapy, School of Medical Technology Xinxiang Medical University Xinxiang China"},{"name":"Henan 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