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Strict social distance and influenza vaccination have been recommended to avoid co\u2010infections between influenza viruses and SARS\u2010CoV\u20102. Scattered reports suggested a protective effect of influenza vaccine on COVID\u201019 development and severity. We analyzed 51 studies on the capacity of influenza vaccination to affect infection with SARS\u2010CoV\u20102, hospitalization, admission to Intensive Care Units (ICU), and mortality. All subjects taken into consideration did not receive any anti\u2010SARS\u2010CoV\u20102 vaccine, although their status with respect to previous infections with SARS\u2010CoV\u20102 is not known. Comparison between vaccinated and not\u2010vaccinated subjects for each of the four endpoints was expressed as odds ratio (OR), with 95% confidence intervals (CIs); all analyses were performed by DerSimonian and Laird model, and Hartung\u2010Knapp model when studies were less than 10. In a total of 61\u2009029\u2009936 subjects from 33 studies, influenza vaccination reduced frequency of SARS\u2010CoV\u20102 infection [OR plus 95% CI = 0.70 (0.65\u22120.77)]. The effect was significant in all studies together, in health care workers and in the general population; distance from influenza vaccination and the type of vaccine were also of importance. In 98\u2009174 subjects from 11 studies, frequency of ICU admission was reduced with influenza vaccination [OR (95% CI) = 0.71 (0.54\u22120.94)]; the effect was significant in all studies together, in pregnant women and in hospitalized subjects. In contrast, in 4\u2009737\u2009328 subjects from 14 studies hospitalization was not modified [OR (95% CI) = 1.05 (0.82\u22121.35)], and in 4\u2009139\u2009660 subjects from 19 studies, mortality was not modified [OR (95% CI) = 0.76 (0.26\u22122.20)]. Our study emphasizes the importance of influenza vaccination in the protection against SARS\u2010CoV\u20102 infection.<\/jats:p>","DOI":"10.1002\/jmv.29343","type":"journal-article","created":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T13:28:45Z","timestamp":1704115725000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Vaccination against influenza viruses reduces infection, not hospitalization or death, from respiratory COVID\u201019: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8217-7672","authenticated-orcid":false,"given":"Antonio E.","family":"Pontiroli","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Salute Universit\u00e0 degli Studi di Milano  Milan 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