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Genome sequencing, the gold standard, faces implementation challenges due to complexity, cost, and limited throughput. The CRISPR\u2010Cas system offers promising potential for rapid variant detection, with advantages such as speed, sensitivity, specificity, and programmability. This review provides an in\u2010depth examination of the applications of CRISPR\u2010Cas in mutation detection specifically for SARS\u2010CoV\u20102. It begins by introducing SARS\u2010CoV\u20102 and existing variant detection platforms. The principles of the CRISPR\u2010Cas system are then clarified, followed by an exploration of three CRISPR\u2010Cas\u2010based mutation detection platforms, which are evaluated from different perspectives. The review discusses strategies for mutation site selection and the utilization of CRISPR\u2010Cas, offering valuable insights for the development of mutation detection methods. 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