{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:22:03Z","timestamp":1790713323840,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human papillomavirus (HPV) is the most common sexually transmitted infection, linked to several types of lesions. HPV, specifically HPV 16, accounts for most of anal cancer cases. In this study, we evaluated the proportion of samples tested positive for HPV and characterized genotypes distribution in anal specimens collected from individuals at risk of anal HPV infection attending from 2018 to 2022 a large Infectious Diseases Department in Italy. The presence of HPV DNA was investigated through a commercial kit detecting 12 HR\u2010HPV, 8 probable\/possible HR\u2010HPV, and 8 LR\u2010HPV genotypes. Among 1514 samples, 84% (1266\/1514) resulted positive for any type of HPV. The prevalence of high\u2010risk HPV types remained high during all the years of the study period, from 2018 to 2022, ranging from 65% to 73%. Most of HR\u2010HPV, LR\u2010HPV and HPV 16 positive samples were collected from men &gt;45 years. HPV 16 was also the most frequent type in men and women. We did not observe significant variations between years in detection of HR\u2010HPV, instead of LR\u2010HPV, that significantly decreased. In conclusion, the high prevalence of oncogenic HPV genotypes underlines the necessity of clear anal HPV screening guidelines and, along with frequent HR\u2010HPV coinfections, reinforces the urge to intensify the anti\u2010HPV vaccination campaign.<\/jats:p>","DOI":"10.1002\/jmv.29370","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T12:14:46Z","timestamp":1704888886000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["High prevalence of high\u2010risk HPV genotypes in individuals attending an infectious diseases clinic from 2018 to 2022 in Milan, Italy"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5999-006X","authenticated-orcid":false,"given":"Alberto","family":"Rizzo","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Microbiology, Virology and Bioemergencies\u2014\u201cLuigi Sacco\u201d University Hospital ASST 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