{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:55:16Z","timestamp":1792587316405,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T00:00:00Z","timestamp":1704844800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    We aimed to assess the epidemiological characteristics of respiratory syncytial virus (RSV) infection in Chinese children at different phases of the coronavirus disease 2019 (COVID\u201019) pandemic, that is, before, during the pandemic and after easing of restrictive measures. We included 123\u2009623 patients aged 0\u201318 years with respiratory infection symptoms who were suspected with RSV infection from January 1, 2019 to June 30, 2023 in Hangzhou Children's Hospital. Clinical information and RSV test result were extracted from the laboratory information system. We calculated the positive rate of RSV detection by age groups, gender, seasons, types of patients and phases of COVID\u201019 pandemic. Nonlinear associations between age and risk of RSV infection in three phases of pandemic were assessed by restricted cubic spline regression models. Among 123\u2009623 patients, 3875 (3.13%) were tested as positive. The highest positive rate was observed in children aged 0\u201328 days (i.e., 12.28%). RSV infection was most prevalent in winter (6.04%), and followed by autumn (2.52%). Although there is no statistical significance regarding the positive rate at three phases of the pandemic, we observed that the rate was lowest during the pandemic and increased after easing the measures in certain age groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05), which was consisted with results from the nonlinear regression analyses. In addition, regression analyses suggested that the age range of children susceptible to RSV got wider, that is, 0\u20133.5 years, after easing all restrictive measures compared with that before (i.e., 0\u20133 years) and during the pandemic (i.e., 0\u20131 year). Based on our findings, we called for attention from health professionals and caregivers on the new epidemiological characteristics of RSV infection in the post\u2010pandemic era after easing the restrictive measures.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29374","type":"journal-article","created":{"date-parts":[[2024,1,10]],"date-time":"2024-01-10T07:24:38Z","timestamp":1704871478000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Epidemiological characteristics of respiratory syncytial virus infection in pediatric patients before, during the COVID\u201019 pandemic and after easing of COVID\u201019 restrictive measures in China"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-2745","authenticated-orcid":false,"given":"Lidan","family":"Hu","sequence":"first","affiliation":[{"name":"Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Yunnan Provincial Key Laboratory of Public Health and Biosafety &amp; School of Public Health  Kunming China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianyu","family":"Lin","sequence":"additional","affiliation":[{"name":"Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingtao","family":"Yan","sequence":"additional","affiliation":[{"name":"Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxuan","family":"Sun","sequence":"additional","affiliation":[{"name":"Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou Dushu Lake Hospital  Suzhou Jiangshu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidan","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Respiratory Hangzhou Children's Hospital  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0619-7580","authenticated-orcid":false,"given":"Guannan","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Child Health Care, Children's Hospital, Zhejiang University School of Medicine National Clinical Research Center for Child Health  Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,10]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-66-10-2111"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00478-0"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy056"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(23)00165-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00195-7"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa1906"},{"issue":"6","key":"e_1_2_11_8_1","first-page":"543","article-title":"Risk of primary infection and reinfection with respiratory syncytial virus","volume":"140","author":"Glezen WP","year":"1986","journal-title":"Am J Dis Children"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197903083001004"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.64762"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30485-3"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.305"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(20)30090-6"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz059"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/piad028"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(18)30310-4"},{"key":"e_1_2_11_17_1","unstructured":"Pneumonia in children. 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