{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:36:19Z","timestamp":1762900579285,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The clinical effect of\u00a0Coronavirus disease 2019 (COVID\u201019)\u00a0on endometrial receptivity and embryo implantation remains unclear. Herein, we aim to investigate whether a COVID\u201019 history adversely affect female pregnancy outcomes after frozen\u2010thawed embryo transfer (FET). This prospective cohort study enrolled 230 women who underwent FET cycles from December 2022 to April 2023 in an academic fertility center. Based on the history of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection before FET, women were divided into the infected group (<jats:italic>n<\/jats:italic>\u2009=\u2009136) and the control group (<jats:italic>n<\/jats:italic>\u2009=\u200994). The primary outcome was the clinical pregnancy rate per cycle. Multivariate logistic regression analysis was conducted to adjust for potential confounders, while subgroup analysis and restricted cubic splines were used to depict the effect of postinfection time interval on FET. The results showed that the clinical pregnancy rate was 59.6% in the infected group and 63.9% in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.513). Similarly, the two groups were comparable in the rates of biochemical pregnancy (69.1% vs. 76.6%; <jats:italic>p<\/jats:italic>\u2009=\u20090.214) and embryo implantation (51.7% vs. 54.5%; <jats:italic>p<\/jats:italic>\u2009=\u20090.628). After adjustment, the nonsignificant association remained between prior infection and clinical pregnancy (OR\u2009=\u20090.78, 95% CI: 0.42\u20131.46). However, the odds for clinical pregnancy were significantly lower in the \u226430 days subgroup (OR\u2009=\u20090.15, 95% CI: 0.03\u20130.77), while no statistical significance was detected for 31\u201360 days and &gt;60 days subgroups compared with the uninfected women. In conclusion, our findings suggested that SARS\u2010CoV\u20102 infection in women had no significant effect on subsequent FET treatment overall, but pregnancy rates tended to be decreased if vitrified\u2010thawed embryos were transferred within 30 days after infection. A 1\u2010month postponement should be rationally recommended, while further studies with larger sample groups and longer follow\u2010up periods are warranted for confirmation.<\/jats:p>","DOI":"10.1002\/jmv.29377","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T11:58:03Z","timestamp":1705579083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pregnancy outcomes after frozen\u2010thawed embryo transfer in women with COVID\u201019 history: A prospective cohort study"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2629-3986","authenticated-orcid":false,"given":"Jialyu","family":"Huang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College Nanchang China"},{"name":"Key Laboratory of Women's Reproductive Health of Jiangxi Province Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, School of Queen Mary Nanchang University Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Life Sciences and Medicine, Reproductive and Genetic Hospital, The First Affiliated Hospital of USTC University of Science and Technology of China Hefei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College Nanchang 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College Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Fan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peipei","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiqi","family":"Xie","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zengming","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Women's Reproductive Health of Jiangxi Province Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8432-7240","authenticated-orcid":false,"given":"Qiongfang","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Jiangxi Maternal and Child Health Hospital, Jiangxi Branch of National Clinical Research Center for Obstetrics and Gynecology Nanchang Medical College Nanchang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai 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