{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T22:20:38Z","timestamp":1784845238129,"version":"3.55.0"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T00:00:00Z","timestamp":1705536000000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hepatic venous pressure gradient (HVPG) is the gold standard for evaluating clinically significant portal hypertension (CSPH). However, reliable noninvasive methods are limited. Our study aims to investigate the diagnostic value of serum Golgi protein 73 (GP73) for CSPH in patients with compensated cirrhosis. The study enrolled 262 consecutive patients with compensated cirrhosis from three centers in China from February 2021 to September 2023, who underwent both serum GP73 tests and HVPG measurements. CSPH was defined as HVPG\u2009\u2265\u200910\u2009mmHg. Diagnostic accuracy was evaluated using the areas under the receiver operating characteristic curve (AUC). The prevalence of CSPH was 56.9% (<jats:italic>n<\/jats:italic>\u2009=\u2009149). There were significant differences between the CSPH and non\u2010CSPH groups in the median serum GP73 level (126.8 vs. 73.1\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). GP73 level showed a significant positive linear correlation with HVPG (<jats:italic>r<\/jats:italic>\u2009=\u20090.459, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The AUC for the diagnosis of CSPH using serum GP73 alone was 0.75 (95% confidence interval [CI] 0.68\u20130.81). Multivariate logistic regression analysis determined that the levels of GP73, platelets and international normalized ratio were independently associated with CSPH. The combination of these three markers was termed \u201cIP73\u201d score with an AUC value of 0.85 (95% CI 0.80\u20130.89) for CSPH. Using 0 as a cut\u2010off value, the specificity and sensitivity of IP73 score were 77.9% and 81.9%, respectively. The IP73 score offers a novel, simple and noninvasive method of assessing CSPH in patients with compensated cirrhosis. A cut\u2010off value of the IP73 score at 0 can distinguish patients with or without CSPH.<\/jats:p>","DOI":"10.1002\/jmv.29380","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T12:02:21Z","timestamp":1705579341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel serum biomarker of Golgi protein 73 for the diagnosis of clinically significant portal hypertension in patients with compensated cirrhosis"],"prefix":"10.1002","volume":"96","author":[{"given":"Shanghao","family":"Liu","sequence":"first","affiliation":[{"name":"Center of Portal Hypertension, Department of Radiology, Zhongda Hospital, School of Medicine Southeast University  Nanjing China"},{"name":"Basic Medicine Research and Innovation Center of Ministry of Education, Zhongda Hospital Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of General Surgery The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of infectious diseases Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Qufu People's Hospital  Qufu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingjie","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal and Hepatology, Beijing You'An Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinong","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinghui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchen","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Gao","sequence":"additional","affiliation":[{"name":"Medical Laboratory Qufu People's Hospital  Qufu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongli","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Hepatology The Third People's Hospital of Taiyuan  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Qufu People's Hospital  Qufu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haolin","family":"Song","sequence":"additional","affiliation":[{"name":"College of Medicine Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiling","family":"He","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiying","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Lanzhou University  Lanzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Gao","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of POCT for Bioemergency and Clinic (No. BZ0329); Beijing Hotgen Biotechnology Inc. 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