{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:15:14Z","timestamp":1772997314313,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pre\u2010existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID\u201019 disease severity. However, the association of candidate single nucleotide variants (SNVs) related to mechanisms of COVID\u201019 complications has been seldom analysed. Our aim was to test and validate the effect of candidate SNVs on COVID\u201019 severity. CARGENCORS (\n                    <jats:italic>CARdiovascular GENetic risk score for Risk Stratification of patients positive for SARS\u2010CoV\u20102 [COVID\u201019] virus<\/jats:italic>\n                    ) is an age\u2010 and sex\u2010matched case\u2010control study with 818 COVID\u201019 cases hospitalized with hypoxemia, and 1636 controls with COVID\u201019 treated at home. The association between severity and SNVs related to CAD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200932), inflammation (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200919), thrombosis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200914), virus infectivity (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200911), and two published to be related to COVID\u201019 severity was tested with adjusted logistic regression models. Two external independent cohorts were used for meta\u2010analysis (SCOURGE and UK Biobank). After adjustment for potential confounders, 14 new SNVs were associated with COVID\u201019 severity in the CARGENCORS Study. These SNVs were related to CAD (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910), thrombosis (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092), and inflammation (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20092). We also confirmed eight SNVs previously related to severe COVID\u201019 and virus infectivity. The meta\u2010analysis showed five SNVs associated with severe COVID\u201019 in adjusted analyses (rs11385942, rs1561198, rs6632704, rs6629110, and rs12329760). We identified 14 novel SNVs and confirmed eight previously related to COVID\u201019 severity in the CARGENCORS data. In the meta\u2010analysis, five SNVs were significantly associated to COVID\u201019 severity, one of them previously related to CAD.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29404","type":"journal-article","created":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T04:45:22Z","timestamp":1706676322000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Genetic characteristics involved in COVID\u201019 severity. 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