{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T21:45:02Z","timestamp":1783460702621,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study investigated the efficacy of the prophylactic human papillomavirus (HPV) vaccine, which was initiated between 2009 and 2013 in Japan. The study involved 1529 eligible women aged 16\u201339 years who visited 11 outpatient clinics in Japan for various reasons. These patients underwent HPV genotype analysis and a Pap test of cervical cell samples. A total of 299 women (19.6%) had received the prophylactic HPV vaccine (bivalent:quadrivalent vaccine ratio\u2009=\u20092:1). Of the 5062 participants in the Japanese Human Papillomavirus Disease Education and Research Survey (J\u2010HERS 2011), which was conducted in the pre\u2010vaccination era, 3236 eligible participants were included as controls. In this study (J\u2010HERS 2021), the highest rate of HPV vaccination (53%) was observed in patients aged 22\u201327 years. Vaccinated individuals exhibited a 49% rate of protection against low\u2010grade intraepithelial lesions (LSILs) and atypical squamous cells, not excluding high\u2010grade squamous intraepithelial lesions (ASCH) or worse (LSIL\/ASCH+), and a 100% rate of protection against high\u2010grade squamous intraepithelial lesions (HSILs) or worse (HSIL+). Significant reductions in HPV16 (95%) and HPV18 (100%) infections were noted, but no differences were observed in HPV6 and HPV11 infections. The prevalences of HPV51 and HPV59 increased with vaccination, although these changes were not confirmed in the comparative study with J\u2010HERS 2011. Comparing the prevaccination (J\u2010HERS 2011) and postvaccination (J\u2010HERS 2021) periods, 43%, 51%, 88%, and 62% reductions in HPV16, HPV18, HPV16\/18, and HPV31\/58 infection rates were observed, respectively. Similarly, 62% and 71% reductions in LSIL\/ASCH+ and HSIL+ rates were noted, respectively. There were 88% and 87% reductions in LSIL\/ASCH+ and HSIL+ rates in 16\u201321\u2010 and 28\u201333\u2010year\u2010old patients, respectively. Bivalent or quadrivalent vaccines provided 100% protection against high\u2010grade squamous cell lesions (suggestive of CIN2 or CIN3) in young women aged &lt;39 years at 9\u201312 years after initiation of Japan's first nationwide HPV vaccination program. Cross\u2010protection against HPV31 and HPV58 is likely to occur, although some HPV\u2010type replacements are inconsistent across vaccination regimens. This demonstrates the effectiveness of the HPV vaccine. However, continuous monitoring of cervical cancer and precancer is necessary in younger generations (born 1997\u20132007), who were rarely vaccinated due to the prolonged suspension of the vaccine recommendations in Japan.<\/jats:p>","DOI":"10.1002\/jmv.29413","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:28:10Z","timestamp":1707276490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effectiveness of prophylactic HPV vaccines against cervical abnormalities and HPV infection in Japan: The J\u2010HERS 2021 multicenter study"],"prefix":"10.1002","volume":"96","author":[{"given":"Yoshihiko","family":"Saeki","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Kanazawa Medical University Kanazawa 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