{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T05:48:28Z","timestamp":1777182508431,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T00:00:00Z","timestamp":1710979200000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Mortality after sustained virological response (SVR) with interferon\u2010free direct\u2010acting antiviral (IFN\u2010free DAA) therapy is crucial for optimizing post\u2010SVR patient care, but it remains unclear, especially regarding non\u2010liver\u2010related mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive post\u2010SVR patients from 14 institutions were stratified into three cohorts: A (without advanced fibrosis and without prior HCC), B (with advanced fibrosis and without prior HCC), and C (curative HCC treatment). We assessed mortality (per 1000 person\u2010years [\/1000PY]) post\u2010SVR. Mortality rates were compared between cohorts A and B and the general population using age\u2010 and sex\u2010adjusted standardized mortality ratio (SMR). Comparison of survival between each cohort was performed using propensity\u2010score (PS) matching with sex, age, and comorbidity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In cohort A (<jats:italic>n<\/jats:italic>\u2009=\u2009762; median age, 65 years), 22 patients died (median follow\u2010up, 36 months); all\u2010cause mortality was 10.0\/1000PY, with 86.4% non\u2010liver\u2010related deaths. In cohort B (<jats:italic>n<\/jats:italic>\u2009=\u2009519; median age, 73 years), 27 patients died (median follow\u2010up, 39 months); all\u2010cause mortality was 16.7\/1000PY, with 88.9% non\u2010liver\u2010related deaths. In both cohorts, malignant neoplasm was the most common cause of death; all\u2010cause mortality was comparable to that of the general population (SMR: 0.96 and 0.92). In cohort C (<jats:italic>n<\/jats:italic>\u2009=\u2009108; median age, 75 years), 15 patients died (median follow\u2010up, 51 months); all\u2010cause mortality was 36.0\/1000PY, with 53.3% liver\u2010related deaths. PS matching showed no significant survival differences between cohorts A and B, both of which had better survival than cohort C.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Mortality varies based on HCC history in the DAA era; nevertheless, attention should be paid to non\u2010liver\u2010related deaths in all post\u2010SVR patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29432","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T03:09:25Z","timestamp":1710990565000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Non\u2010liver\u2010related mortality in the DAA era: Insights from post\u2010SVR patients with and without previous HCC 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