{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:59:58Z","timestamp":1792216798538,"version":"4.4.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:00:00Z","timestamp":1707091200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Enterovirus C99 (EV\u2010C99) is a newly identified EV serotype within the species Enterovirus C. Few studies on EV\u2010C99 have been conducted globally. More information and research on EV\u2010C99 are needed to assess its genetic characteristics, phylogenetic relationships, and associations with enteroviral diseases. Here, the phylogenetic characteristics of 11 Chinese EV\u2010C99 strains have been reported. The full\u2010length genomic sequences of these 11 strains show 79.4\u201380.5% nucleotide identity and 91.7\u201394.3% amino acid (aa) identity with the prototype EV\u2010C99. A maximum likelihood phylogenetic tree constructed based on the entire\n                    <jats:italic>VP1<\/jats:italic>\n                    coding region identified 13 genotypes (A\u2013M), revealing a high degree of variation among the EV\u2010C99 strains. Phylogeographic analysis showed that the Xinjiang Uygur Autonomous Region is an important source of EV\u2010C99 epidemics in various regions of China. Recombination analysis revealed inter\u2010serotype recombination events of 16 Chinese EV\u2010C99 strains in 5\u2032 untranslated regions and\n                    <jats:italic>3D<\/jats:italic>\n                    regions, resulting in the formation of a single recombination form. Additionally, the Chinese strain of genotype J showed rich aa diversity in the\n                    <jats:italic>P1<\/jats:italic>\n                    region, indicating that the genotype J of EV\u2010C99 is still going through variable dynamic changes. This study contributes to the global understanding of the EV\u2010C99 genome sequence and holds substantial implications for the surveillance of EV\u2010C99.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29449","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T03:34:20Z","timestamp":1707276860000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic characterization and molecular epidemiological analysis of enterovirus C99 in China"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0509-1253","authenticated-orcid":false,"given":"Ruyi","family":"Cong","sequence":"first","affiliation":[{"name":"School of Public Health Shandong First Medical University &amp; Shandong Academy of Medical Sciences Jinan China"},{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"},{"name":"National Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"},{"name":"National Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianjiao","family":"Ji","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"},{"name":"National Polio Laboratory, WHO WPRO Regional Polio Reference Laboratory, National Health Commission Key Laboratory for Biosafety, National Health Commission Key Laboratory for Medical Virology, National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and Prevention Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Sun","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Intelligent Tracking and 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