{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T09:35:40Z","timestamp":1785231340566,"version":"3.55.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T00:00:00Z","timestamp":1706832000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Primary Epstein\u2010Barr virus (EBV) infection occasionally causes EBV\u2010infectious mononucleosis (EBV\u2010IM) and EBV\u2010hemophagocytic lymphohistiocytosis (EBV\u2010HLH). Although EBV\u2010IM is mostly mild and self\u2010limiting, EBV\u2010HLH is a life\u2010threatening disease characterized by excessive immune activation. However, the pathogenesis of EBV\u2010HLH is yet to be fully elucidated. A diagnostic biomarker for EBV\u2010HLH is desirable because early diagnosis and treatment are critical for the effective management of patients. In this study, the proteomic profiling of plasma was performed using liquid chromatography\u2010mass spectrometry to identify proteins specific to EBV\u2010IM and EBV\u2010HLH. Furthermore, pathway analysis was performed for the proteins upregulated in patients with EBV\u2010IM and EBV\u2010HLH. Compared to healthy controls, 63 and 18 proteins were upregulated in patients with EBV\u2010IM and EBV\u2010HLH, respectively. Pathway and process enrichment analyses revealed that the complement system was the most enriched category of upregulated proteins in EBV\u2010IM, whereas proteins related to immune effector processes were the most enriched in EBV\u2010HLH. Among the 18 proteins upregulated in EBV\u2010HLH, seven were exclusive to EBV\u2010HLH. These specific proteins were associated with three pathways, and apolipoprotein E was commonly found in all the pathways. Proteomic analysis may provide new insights into the host response to EBV infection and the pathogenesis of EBV\u2010related diseases.<\/jats:p>","DOI":"10.1002\/jmv.29450","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T04:04:41Z","timestamp":1706846681000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of plasma proteomic profiles of patients with Epstein\u2010Barr virus\u2010associated hemophagocytic lymphohistiocytosis and infectious mononucleosis"],"prefix":"10.1002","volume":"96","author":[{"given":"Kazunori","family":"Haruta","sequence":"first","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine Nagoya Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Nagoya University Graduate School of Medicine 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