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Prophylactic vaccines are available but antiviral drugs are not. Novel targets for therapy are urgently needed. Alternative RNA splicing is extensively used by HPVs to express all their genes and HPV16 is no exception. This process must function to perfection since mis\u2010splicing could perturb the HPV gene expression program by altering mRNA levels or by generating dysfunctional mRNAs. Cis\u2010acting RNA elements on the viral mRNAs and their cognate cellular trans\u2010acting factors control papillomavirus RNA splicing. The precise but delicate nature of the splicing process renders splicing sensitive to interference. As such, papillomavirus RNA splicing is a potential target for therapy. Here we summarize our current understanding of cis\u2010acting HPV16 RNA elements that control HPV16 mRNA splicing via cellular proteins and discuss how they may be exploited as targets for therapy to papillomavirus infections and cancer.<\/jats:p>","DOI":"10.1002\/jmv.29473","type":"journal-article","created":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T07:05:55Z","timestamp":1708067155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["RNA elements that control\u00a0human papillomavirus mRNA splicing\u2010targets for therapy?"],"prefix":"10.1002","volume":"96","author":[{"given":"Stefan","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Medical Biochemistry and Microbiology Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengjun","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences 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