{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:15:35Z","timestamp":1772997335054,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T00:00:00Z","timestamp":1708387200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Choroidal neovascularization (CNV) is a serious condition that affects the retina, causing partial or complete blindness in people of different ages. While CNV is a common occurrence in various chorioretinopathies, research on its occurrence in neonates is limited. Human cytomegalovirus (HCMV) is a significant health threat to neonates, with a strong association with retinal angiogenesis. However, there has been limited investigation into HCMV\u2010associated CNV progression. In this article, we extensively studied the expression of different inflammatory cytokines and chemokines during latent HCMV\u2010associated retinal neovascularization. Our research found that HCMV\u2010induced CNV progression was significantly prominent in the presence of AT2R\u2010dependent angiogenesis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas in the absence of HCMV, AT1R\u2010dependent CCL\u20105\u2010mediated angiogenesis was documented. We also observed significant increases in CCL\u201019, CCL\u201021 chemokine responses, followed by CCR\u20107 chemokine receptor activation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) in HCMV\u2010induced CNV patients compared to HCMV non\u2010induced CNV groups. Furthermore, significant changes in predictive chemokine markers of HCMV\u2010induced CNV were positively correlated with HCMV viremia. These immunological alterations ultimately lead to the switching of NF\u03baB canonical and noncanonical pathways, respectively, in HCMV\u2010induced neonatal CNV and HCMV non\u2010induced CNV. This clinical observation presents a novel hypothesis that ocular HCMV latency poses a noteworthy risk factor for the progression of retinal neovascularization through a distinctive immunological signaling pathway. The current study represents the first of its kind to report on this association, which may have significant implications for the clinical management of patients with ocular HCMV.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29478","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T13:13:36Z","timestamp":1708434816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Progression of retinal choroidal neovascularization\u00a0by latent human cytomegalovirus infection and immunological signaling among neonatal patients admitted to tertiary care hospital"],"prefix":"10.1002","volume":"96","author":[{"given":"Debsopan","family":"Roy","sequence":"first","affiliation":[{"name":"Virus Research Laboratory ICMR\u2010NICED Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aroni","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, School of Biotechnology and Bioscience Brainware University Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lopamudra","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pediatrics IPGME&amp;R, SSKM Hospital Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6324-3905","authenticated-orcid":false,"given":"Nilanjan","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Virus Research Laboratory ICMR\u2010NICED Kolkata West Bengal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190206105943"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2013.155"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2012.04.004"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12757"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000322"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-3209-8_28"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2004.11.064"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2005.07.021"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-310445"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.4236\/oji.2018.81001"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.2.248"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800037105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2010.09.011"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11605-007-0403-9"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213453"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030467"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0900-0"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.600163"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0601947103"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2004.11.009"},{"key":"e_1_2_10_22_1","article-title":"Subversion of immune response by human cytomegalovirus","volume":"1","author":"Dix RD","year":"2019","journal-title":"Front Immunol"},{"issue":"5","key":"e_1_2_10_23_1","first-page":"123","article-title":"Cytomegalovirus UL83 gene as diagnostic marker for preliminary infection in pregnant women in AL\u2010Najaf City","volume":"11","author":"Yasir SJ","year":"2020","journal-title":"Syst Rev Pharm"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01251-08"},{"key":"e_1_2_10_25_1","unstructured":"Primer3. 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