{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:17:13Z","timestamp":1792441033993,"version":"4.5.0"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T00:00:00Z","timestamp":1709856000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Orthostatic intolerance (OI), including postural orthostatic tachycardia syndrome (PoTS) and orthostatic hypotension (OH), are often reported in long covid, but published studies are small with inconsistent results. We sought to estimate the prevalence of objective OI in patients attending long covid clinics and healthy volunteers and associations with OI symptoms and comorbidities.\u00a0Participants with a diagnosis of long covid were recruited from eight\u00a0UK long covid clinics, and healthy volunteers from general population. All undertook standardized National Aeronautics and Space Administration Lean Test (NLT). Participants' history of typical OI symptoms (e.g., dizziness, palpitations) before and during the NLT were recorded.\u00a0Two hundred seventy\u2010seven long covid patients and 50 frequency\u2010matched healthy volunteers were tested. Healthy volunteers had no history of OI symptoms or symptoms during NLT or PoTS, 10% had asymptomatic OH. One hundred thirty\u00a0(47%) long covid patients had previous history of OI symptoms and 144 (52%) developed symptoms during the NLT. Forty\u2010one\u00a0(15%) had an abnormal NLT, 20 (7%) met criteria for PoTS, and 21 (8%) had OH. Of patients with an abnormal NLT, 45% had no prior symptoms of OI. Relaxing the diagnostic thresholds for PoTS from two consecutive abnormal readings to one abnormal reading during the NLT, resulted in 11% of long covid participants (an additional 4%) meeting criteria for PoTS, but not in healthy volunteers.\u00a0More than half of long covid patients experienced OI symptoms during NLT and more than one in 10\u00a0patients met the criteria for either PoTS or OH, half of whom did not report previous typical OI symptoms. We therefore recommend all patients attending long covid clinics are offered an NLT and appropriate management commenced.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jmv.29486","type":"journal-article","created":{"date-parts":[[2024,3,8]],"date-time":"2024-03-08T05:14:09Z","timestamp":1709874849000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Prevalence of orthostatic intolerance in long covid clinic patients and healthy volunteers: A multicenter study"],"prefix":"10.1002","volume":"96","author":[{"given":"Cassie","family":"Lee","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-3096","authenticated-orcid":false,"given":"Darren C.","family":"Greenwood","sequence":"additional","affiliation":[{"name":"School of Medicine University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harsha","family":"Master","sequence":"additional","affiliation":[{"name":"Covid Assessment and Rehabilitation Service, Hertfordshire Community NHS Trust Welwyn Garden City UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kumaran","family":"Balasundaram","sequence":"additional","affiliation":[{"name":"NIHR Leicester Biomedical Research Centre, Respiratory &amp; 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