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The world is continuously concerned about the cytokine storms induced by the interaction between SARS\u2010CoV\u20102 and host, long COVID, breakthrough infections postvaccination, and the impact of SARS\u2010CoV\u20102 variants. BCR\u2010CDR3 repertoire serves as a molecular target for monitoring the antiviral response \u201ctrace\u201d of B cells, evaluating the effects, mechanisms, and memory abilities of individual responses to B cells, and has been successfully applied in analyzing the infection mechanisms, vaccine improvement, and neutralizing antibodies preparation of influenza virus, HIV, MERS, and Ebola virus. Based on research on BCR\u2010CDR3 repertoire of COVID\u201019 patients and volunteers who received different SARS\u2010CoV\u20102 vaccines in multiple laboratories worldwide, we focus on analyzing the characteristics and changes of BCR\u2010CDR3 repertoire, such as diversity, clonality, <jats:italic>V&amp;J<\/jats:italic> genes usage and pairing, SHM, CSR, shared CDR3 clones, as well as the summary on BCR sequences targeting virus\u2010specific epitopes in the preparation and application research of SARS\u2010CoV\u20102 potential therapeutic monoclonal antibodies. This review provides comparative data and new research schemes for studying the possible mechanisms of differences in B cell response between SARS\u2010CoV\u20102 infection or vaccination, and supplies a foundation for improving vaccines after SARS\u2010CoV\u20102 mutations and potential antibody therapy for infected individuals.<\/jats:p>","DOI":"10.1002\/jmv.29488","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T05:50:48Z","timestamp":1709099448000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The characteristics of BCR\u2010CDR3 repertoire in COVID\u201019 patients and SARS\u2010CoV\u20102 vaccinated volunteers"],"prefix":"10.1002","volume":"96","author":[{"given":"Jiaping","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Immunology, Center of Immunomolecular Engineering, Innovation &amp; Practice Base for Graduate Students Education Zunyi Medical University  Zunyi Guizhou China"},{"name":"Fushun People's Hospital  Zigong Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center of Immunomolecular Engineering, Innovation &amp; Practice Base for Graduate Students Education Zunyi Medical University  Zunyi Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center of Immunomolecular Engineering, Innovation &amp; Practice Base for Graduate Students Education Zunyi Medical University  Zunyi Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6960-4003","authenticated-orcid":false,"given":"Xinsheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center of Immunomolecular Engineering, Innovation &amp; Practice Base for Graduate Students Education Zunyi Medical University  Zunyi Guizhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22030992"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1719902"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0327-4"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.04.026"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl-2021-0249"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25987"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26776"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26387"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.15698\/cst2020.04.216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30566-3"},{"issue":"19","key":"e_1_2_10_12_1","first-page":"1861","article-title":"Clinical characteristics of Covid\u201019 in China","volume":"382","author":"Guan WJ","year":"2020","journal-title":"N Engl J Med"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molliq.2022.118633"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eng.2020.10.003"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.001"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.611004"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.09.002"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pulmoe.2021.03.008"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.5962\/bhl.title.8281"},{"key":"e_1_2_10_21_1","volume-title":"Janeway's Immunobiology","author":"Murphy K","year":"2017"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06890"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07930"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02002-17"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad5224"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-021-00592-1"},{"key":"e_1_2_10_27_1","unstructured":"COVID\u201019 Vaccines Tracker. 2023.https:\/\/covid19.trackvaccines.org\/"},{"issue":"12","key":"e_1_2_10_28_1","article-title":"Efficacy and safety of COVID\u201019 vaccines","volume":"12","author":"Gra\u00f1a C","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_10_29_1","unstructured":"MathieuE RitchieH Rod\u00e9s\u2010GuiraoL et al. 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