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One cluster with higher fractions of immune cells and more active inflammatory\u2010related pathways was called the Immunity\u2010High (Immunity\u2010H) group, and the other one was called the Immunity\u2010Low group. We explored impacts of the method on COVID\u201019 treatment. First, given that the Immunity\u2010H group was mainly enriched in inflammatory\u2010related pathways and had higher fractions of inflammatory cells, the Immunity\u2010H group may obtain more curative effects from anti\u2010inflammatory treatment. Second, we searched some hot genes from the PubMed platform that had been studied by researchers and found these genes upregulated in the Immunity\u2010H group, so we speculated the Immunity\u2010H group and Immunity\u2010Low group may have different curative effects from drugs targeting these genes. Finally, we screened out hub genes for the Immunity\u2010H group and predicted potential drugs for these hub genes by a public data set (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/dgidb.genome.wustl.edu\">http:\/\/dgidb.genome.wustl.edu<\/jats:ext-link>). These hub genes are significantly upregulated in the Immunity\u2010H group and neutrophils so that the Immunity\u2010H group may obtain different treatment results from potential drugs compared with the Immunity\u2010Low group. Therefore, the cluster method may provide help in drug development and administration for COVID\u201019 patients.<\/jats:p>","DOI":"10.1002\/jmv.29497","type":"journal-article","created":{"date-parts":[[2024,3,4]],"date-time":"2024-03-04T05:41:11Z","timestamp":1709530871000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Identifying COVID\u201019 subtypes by\u00a0single\u2010sample gene set enrichemnt analysis and providing guidance for sensitive drug selection"],"prefix":"10.1002","volume":"96","author":[{"given":"Nan","family":"Xiong","sequence":"first","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College  Kunming China"},{"name":"Graduate School of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6786-049X","authenticated-orcid":false,"given":"Qiangming","family":"Sun","sequence":"additional","affiliation":[{"name":"Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College  Kunming China"},{"name":"Yunnan Key Laboratory of Vaccine Research &amp; 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