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And methods for developing multi\u2010target drugs are limited in terms of exploring drug targets with similar functions or structures. In this study, four rounds of structural design and modification on salinomycin were performed for novel antiviral compounds. It was based on the strategy of similar topological structure binding properties of protein targets (STSBPT), resulting in the high\u2010efficient synthesis of the optimal compound M1, which could bind to aminopeptidase N and 3C\u2010like protease from hosts and viruses, respectively, and exhibit a broad\u2010spectrum antiviral effect against severe acute respiratory syndrome CoV 2 pseudovirus, porcine epidemic diarrhea virus, transmissible gastroenteritis virus, feline infectious peritonitis virus and mouse hepatitis virus. Furthermore, the drug\u2010binding domains of these proteins were found to be structurally similar based on the STSBPT strategy. The compounds screened and designed based on this region were expected to have broad\u2010spectrum and strong antiviral activities. The STSBPT strategy is expected to be a fundamental tool in accelerating the discovery of multiple targets with similar effects and drugs.<\/jats:p>","DOI":"10.1002\/jmv.29512","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T08:31:54Z","timestamp":1710405114000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Design and synthesis of APN and 3CLpro dual\u2010target inhibitors based on STSBPT with anticoronavirus activity"],"prefix":"10.1002","volume":"96","author":[{"given":"Youle","family":"Zheng","sequence":"first","affiliation":[{"name":"National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin","family":"Feng","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanbin","family":"Song","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University Hubei Hongshan Laboratory Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Yu","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Ling","sequence":"additional","affiliation":[{"name":"National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues Huazhong Agricultural University Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University Hubei Hongshan Laboratory Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijiao","family":"Xie","sequence":"additional","affiliation":[{"name":"Hangzhou Yanqu Information Technology Co., Ltd. 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