{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:41:33Z","timestamp":1789656093870,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T00:00:00Z","timestamp":1710201600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010425","name":"Tri-Service General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatitis B virus (HBV) infection significantly impacts Asian populations. The influences of continuous HBV antigen and inflammatory stimulation to T cells in chronic hepatitis B (CHB) remain unclear. In this study, we first conducted bioinformatics analysis to assess T\u2010cell signaling pathways in CHB patients. In a Taiwanese cohort, we examined the phenotypic features of HBV\n                    <jats:sub>core<\/jats:sub>\n                    \u2010specific T cells and their correlation with clinical parameters. We used core protein overlapping peptides from the Taiwan prevalent genotype B HBV to investigate the antiviral response and the functional implication of HBV\u2010specific T cells. In line with Taiwanese dominant HLA\u2010alleles, we also evaluated ex vivo HBV\n                    <jats:sub>core<\/jats:sub>\n                    \u2010specific T cells by pMHC\u2010tetramers targeting epitopes within HBV core protein. Compared to healthy subjects, we disclosed CD8 T cells from CHB patients had higher activation marker CD38 levels but showed an upregulation in the inhibitory receptor PD\u20101. Our parallel study showed HBV\u2010specific CD8 T cells were more activated with greater PD\u20101 expression than CMV\u2010specific subset and bulk CD8 T cells. Moreover, our longitudinal study demonstrated a correlation between the PD\u20101 fluctuation pattern of HBV\n                    <jats:sub>core<\/jats:sub>\n                    \u2010specific CD8 T cells and liver inflammation in CHB patients. Our research reveals the HBV core antigen\u2010mediated immunopathologic profile of CD8 T cells in chronic HBV infection. Our findings suggest the PD\u20101 levels of HBV\n                    <jats:sub>core<\/jats:sub>\n                    \u2010specific CD8 T cells can be used as a valuable indicator of personal immune response for clinical application in hepatitis management.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29515","type":"journal-article","created":{"date-parts":[[2024,3,12]],"date-time":"2024-03-12T07:08:51Z","timestamp":1710227331000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical implications of hepatitis B virus core antigen\u2010mediated immunopathologic T cell responses in chronic hepatitis B"],"prefix":"10.1002","volume":"96","author":[{"given":"Li\u2010Tzu","family":"Wang","sequence":"first","affiliation":[{"name":"School of Medical Laboratory Science and Biotechnology, College of Medical Science and Technology Taipei Medical University Taipei Taiwan"},{"name":"Ph.D. Program in Medical 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