{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:23:28Z","timestamp":1759451008081,"version":"build-2065373602"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Peripheral arterial occlusive disease (PAOD) is a clinical manifestation of systemic atherosclerosis and is always associated with cerebrovascular disease and various complications. The aim of our study is to evaluate the relationship between the coronavirus disease 2019 (COVID\u201019) infection and the subsequent PAOD development. A retrospective cohort study was conducted and individuals with COVID\u201019 infection were identified from the TriNetX analytics platform. A total of 2\u2009206\u2009065 patients with COVID\u201019 infection and 2\u2009206\u2009065 patients without COVID\u201019 infection were recruited after exclusion and matching. The primary outcome was the development of PAOD after the COVID\u201019 infection. The Cox proportional hazard regression was adopted to yield the hazard ratio (HR) and 95% confidence interval (CI) of PAOD between groups. After the whole follow\u2010up period, the incidence of PAOD was significantly higher in the COVID\u201019 group at both the 3\u2010month follow\u2010up (HR: 1.27, 95% CI: 1.24\u20131.30) and the 12\u2010month follow\u2010up (HR: 1.33, 95% CI: 1.31\u20131.35) The Kaplan\u2010Meier analysis with the log\u2010rank test demonstrated a higher cumulative probability of PAOD in the COVID\u201019 group compared to the non\u2010COVID\u201019 group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In stratified analysis using 65 years as the threshold, both age groups in the COVID\u201019 group exhibited a higher risk of PAOD. Similarly, in the sex and race stratified analysis, the COVID\u201019 group performed a higher risk of PAOD in both subgroups. In conclusion, the COVID\u201019 infections are strongly associated with an increment of PAOD incidence.<\/jats:p>","DOI":"10.1002\/jmv.29519","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T07:34:58Z","timestamp":1710142498000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the incidence of peripheral arterial occlusive disease following COVID\u201019 infection: A retrospective cohort study"],"prefix":"10.1002","volume":"96","author":[{"given":"Liang\u2010Tsai","family":"Yeh","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Changhua Christian Hospital Changhua Taiwan"},{"name":"School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi\u2010Ho","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu\u2010Hsun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Yi","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Ophthalmology Nobel Eye Institute Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun\u2010Fa","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Medical Research Chung Shan Medical University Hospital Taichung Taiwan"},{"name":"Institute of Medicine Chung Shan Medical University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3978-5576","authenticated-orcid":false,"given":"Chao\u2010Bin","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, School of Medicine Chung Shan Medical University Taichung Taiwan"},{"name":"Department of Emergency Medicine Chung Shan Medical University Hospital Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_9_2_1","DOI":"10.1016\/S0140-6736(20)30183-5"},{"doi-asserted-by":"publisher","key":"e_1_2_9_3_1","DOI":"10.3390\/v13020202"},{"doi-asserted-by":"publisher","key":"e_1_2_9_4_1","DOI":"10.1016\/j.intimp.2020.107262"},{"doi-asserted-by":"publisher","key":"e_1_2_9_5_1","DOI":"10.1056\/NEJMsr2105280"},{"doi-asserted-by":"publisher","key":"e_1_2_9_6_1","DOI":"10.1016\/S0140-6736(21)00439-6"},{"doi-asserted-by":"publisher","key":"e_1_2_9_7_1","DOI":"10.1038\/s41590-021-01104-y"},{"issue":"7","key":"e_1_2_9_8_1","first-page":"599","article-title":"Long COVID\u201019 and the heart: is cardiac mitochondria the missing link?","volume":"38","author":"Chang X","year":"2023","journal-title":"Antioxid Redox Signal"},{"doi-asserted-by":"publisher","key":"e_1_2_9_9_1","DOI":"10.1038\/s41579-022-00846-2"},{"doi-asserted-by":"publisher","key":"e_1_2_9_10_1","DOI":"10.1016\/j.eclinm.2022.101619"},{"doi-asserted-by":"publisher","key":"e_1_2_9_11_1","DOI":"10.1038\/s41591-022-01689-3"},{"doi-asserted-by":"publisher","key":"e_1_2_9_12_1","DOI":"10.1136\/bmj.j5842"},{"issue":"2","key":"e_1_2_9_13_1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.23736\/S0392-9590.18.03897-X","article-title":"Peripheral arterial occlusive disease and perioperative risk","volume":"37","author":"Poredos P","year":"2018","journal-title":"Int Angiol: J Int Union Angiol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_14_1","DOI":"10.1016\/j.amjmed.2019.04.043"},{"doi-asserted-by":"publisher","key":"e_1_2_9_15_1","DOI":"10.1007\/s11239-020-02230-4"},{"doi-asserted-by":"publisher","key":"e_1_2_9_16_1","DOI":"10.1016\/j.tcm.2020.10.005"},{"doi-asserted-by":"publisher","key":"e_1_2_9_17_1","DOI":"10.1161\/CIRCULATIONAHA.120.050809"},{"doi-asserted-by":"publisher","key":"e_1_2_9_18_1","DOI":"10.1024\/0301-1526\/a000386"},{"doi-asserted-by":"publisher","key":"e_1_2_9_19_1","DOI":"10.3390\/ijms20122936"},{"doi-asserted-by":"publisher","key":"e_1_2_9_20_1","DOI":"10.1016\/j.jdiacomp.2020.107623"},{"issue":"3","key":"e_1_2_9_21_1","first-page":"233","article-title":"Prevalence of peripheral arterial occlusive disease and associated risk factors in a sample of Southern sardinian population","volume":"13","author":"Binaghi F","year":"1994","journal-title":"Int Angiol"},{"doi-asserted-by":"publisher","key":"e_1_2_9_22_1","DOI":"10.2165\/00129784-200707010-00005"},{"doi-asserted-by":"publisher","key":"e_1_2_9_23_1","DOI":"10.1007\/s00296-017-3828-9"},{"doi-asserted-by":"publisher","key":"e_1_2_9_24_1","DOI":"10.1182\/blood.2021012250"},{"doi-asserted-by":"publisher","key":"e_1_2_9_25_1","DOI":"10.1159\/000060649"},{"doi-asserted-by":"publisher","key":"e_1_2_9_26_1","DOI":"10.1371\/journal.ppat.1011063"},{"doi-asserted-by":"publisher","key":"e_1_2_9_27_1","DOI":"10.1152\/ajpcell.00375.2021"},{"doi-asserted-by":"publisher","key":"e_1_2_9_28_1","DOI":"10.3389\/fcvm.2022.859505"},{"doi-asserted-by":"publisher","key":"e_1_2_9_29_1","DOI":"10.1161\/CIRCRESAHA.121.317997"},{"doi-asserted-by":"publisher","key":"e_1_2_9_30_1","DOI":"10.1111\/all.14657"}],"container-title":["Journal of Medical Virology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jmv.29519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T04:26:00Z","timestamp":1759379160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jmv.29519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/jmv.29519"],"URL":"https:\/\/doi.org\/10.1002\/jmv.29519","archive":["Portico"],"relation":{},"ISSN":["0146-6615","1096-9071"],"issn-type":[{"type":"print","value":"0146-6615"},{"type":"electronic","value":"1096-9071"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2024-01-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e29519"}}