{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T23:17:47Z","timestamp":1767136667800,"version":"build-2238731810"},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T00:00:00Z","timestamp":1711411200000},"content-version":"vor","delay-in-days":25,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170669"],"award-info":[{"award-number":["82170669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271784"],"award-info":[{"award-number":["82271784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Virology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Amidst the COVID\u201019 pandemic, uncertainty persists among caregivers regarding the vaccination of pediatric liver transplant recipients (PLTRs). This study evaluates the immunogenicity and safety of COVID\u201019 vaccination in this vulnerable population. A cohort of 30 PLTRs underwent sequential vaccinations with an inactivated SARS\u2010CoV\u20102 vaccine followed by an Ad5\u2010nCoV booster. We collected and analyzed blood samples pre\u2010vaccination and four weeks post\u2010vaccination to quantify antibody and IGRA (IFN\u2010\u03b3 Release Assay) levels. We also documented any adverse reactions occurring within seven days post\u2010vaccination and monitored participants for infections over six months post\u2010vaccination, culminating in a comprehensive statistical analysis. The Ad5\u2010nCoV booster substantially elevated IgG (T1: 18.01, 20%; T2: 66.61, 55%) and nAb (T1: 119.29, 8%; T2: 3799.75, 80%) levels, as well as T\u2010cell responses, in comparison to the initial dose. The first dose was associated with some common adverse reactions, such as injection site pain (13.3%) and fever (16.6%), but a low rate of systemic reactions (16.0%). There was no significant difference in Omicron infection rates or RTPCR conversion times between vaccinated and unvaccinated groups. Notably, following Omicron infection, vaccinated individuals exhibited significantly higher SARS\u2010CoV\u20102 IgG and nAb titers (average IgG: 231.21 vs. 62.09 S\/CO,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0003; nAb: 5246.11 vs. 2592.07 IU\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.0002). The use of inactivated vaccines followed by an Ad5\u2010nCoV booster in PLTRs is generally safe and elicits a robust humoral response, albeit with limited T\u2010cell responses.\n                  <\/jats:p>","DOI":"10.1002\/jmv.29543","type":"journal-article","created":{"date-parts":[[2024,3,26]],"date-time":"2024-03-26T03:24:53Z","timestamp":1711423493000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the effectiveness and safety of sequential vaccination with inactivated SARS\u2010CoV\u20102 vaccine and Ad5\u2010nCoV booster in pediatric liver transplant recipients"],"prefix":"10.1002","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0505-5601","authenticated-orcid":false,"given":"Zhigang","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huimin","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Sun","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yefeng","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Clinical Research Institute Shanghai Jiao Tong University School of Medicine Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxuan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Shanghai Children's Medical Center, National Children's Medical Center, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qing","family":"Cao","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center\u2013bioM\u00e9rieux Laboratory, Shanghai Children's Medical Center, School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji","family":"Liang","sequence":"additional","affiliation":[{"name":"Shanghai Children's Medical Center\u2013bioM\u00e9rieux Laboratory, Shanghai Children's Medical Center, School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"bioM\u00e9rieux (Shanghai) Company Limited Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, Renji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China"},{"name":"Shanghai Engineering Research Center of Transplantation and Immunology Shanghai China"},{"name":"Shanghai Institute of Transplantation Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Liver Surgery and Liver Transplantation, 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